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    Mechanobiology of the cell surface: Probing its remodeling dynamics using membrane tether pulling assays with optical tweezers

    JULIANA SOARES1,2,#, DOUGLAS G. FREITAS1,3,#, PEDRO S. LOURENÇO1,4, JEFTE FARIAS1,5, BRUNO PONTES1,2,3,4,5,*

    BIOCELL, Vol.46, No.9, pp. 2009-2013, 2022, DOI:10.32604/biocell.2022.019969 - 18 May 2022

    Abstract Mammalian cell surfaces consist of the plasma membrane supported by an underneath cortical cytoskeleton. Together, these structures can control not only the shape of cells but also a series of cellular functions ranging from migration and division to exocytosis, endocytosis and differentiation. Furthermore, the cell surface is capable of exerting and reacting to mechanical forces. Its viscoelastic properties, especially membrane tension and bending modulus, are fundamental parameters involved in these responses. This viewpoint summarizes our current knowledge on how to measure the viscoelastic properties of cell surfaces employing optical tweezers-based tether assays, paving the way More >

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