Wangping Duan∗, Lei Wei†, Juntao Zhang∗, Yongzhuang Hao∗, Chunjiang Li∗, Hao Li∗, Qi Li∗, Quanyou Zhang‡, Weiyi Chen‡, Xiaochun Wei∗,§
Molecular & Cellular Biomechanics, Vol.8, No.4, pp. 253-274, 2011, DOI:10.3970/mcb.2011.008.253
Abstract The cytoskeleton network is believed to play an important role in the biomechanical properties of the chondrocyte. Ours and other laboratories have demonstrated that chondrocytes exhibit a viscoelastic solid creep behavior in vitro and that viscoelastic properties decrease in osteoarthritic chondrocytes. In this study, we aimed to understand whether the alteration of viscoelastic properties is associated with changes in cytoskeleton components of ageing chondrocytes from rabbit knee articular cartilage. Three age groups were used for this study: young (2-months-old, N=23), adult (8-months-old, N=23), and old (31-months-old, N=23) rabbit groups. Cartilage structure and proteoglycan and type II collagen content were determined… More >
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