JINGJING CHEN¹, DAN WANG², ZEQUN WANG², MENGYUAN HAN⁴, HOUQING YIN², WENTING ZHOU⁴, RIBAI YAN⁵, YAN PAN^2,3,*

Oncology Research, Vol.32, No.5, pp. 911-923, 2024, DOI:10.32604/or.2023.042384

Abstract Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-PDT. Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901… More > Graphic Abstract

Xue Wang^1,2, Weizhou Zhu^1,2, Zhao Cui^2,3, Xingguang Qian^2,3, Jinke Yang^1,2, Jianjun Jia^1,2,*, Yikun Wang^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 325-337, 2024, DOI:10.32604/cmes.2024.048804

Abstract The gravitational wave spacecraft is a complex multi-input multi-output dynamic system. The gravitational wave detection mission requires the spacecraft to achieve single spacecraft with two laser links and high-precision control. Establishing one spacecraft with two laser links, compared to one spacecraft with a single laser link, requires an upgraded decoupling algorithm for the link establishment. The decoupling algorithm we designed reassigns the degrees of freedom and forces in the control loop to ensure sufficient degrees of freedom for optical axis control. In addressing the distinct dynamic characteristics of different degrees of freedom, a transfer function compensation method is used in… More >

Dawei Ruan¹, Mingwei Hu^1,2,3,4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 821-844, 2024, DOI:10.32604/cmes.2024.048392

Abstract The specialized equipment utilized in long-line tunnel engineering is evolving towards large-scale, multifunctional, and complex orientations. The vibration caused by the high-frequency units during regular operation is supported by the foundation of the units, and the magnitude of vibration and the operating frequency fluctuate in different engineering contexts, leading to variations in the dynamic response of the foundation. The high-frequency units yield significantly diverse outcomes under different startup conditions and times, resulting in failure to meet operational requirements, influencing the normal function of the tunnel, and causing harm to the foundation structure, personnel, and property in severe cases. This article… More >

Jipeng Xie^1,2, Guolai Yang^1,*, Liqun Wang¹, Lei Li¹

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 793-819, 2024, DOI:10.32604/cmes.2024.048174

Abstract To enhance the comprehensive performance of artillery internal ballistics—encompassing power, accuracy, and service life—this study proposed a multi-stage multidisciplinary design optimization (MS-MDO) method. First, the comprehensive artillery internal ballistic dynamics (AIBD) model, based on propellant combustion, rotation band engraving, projectile axial motion, and rifling wear models, was established and validated. This model was systematically decomposed into subsystems from a system engineering perspective. The study then detailed the MS-MDO methodology, which included Stage I (MDO stage) employing an improved collaborative optimization method for consistent design variables, and Stage II (Performance Optimization) focusing on the independent optimization of local design variables and… More >

Zun-Di Huang¹, Zhen-Bin Zhou^1,2,3, Ning Chang¹, Zheng-Wei Chen^2,3,*, Su-Mei Wang^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 975-996, 2024, DOI:10.32604/cmes.2024.047664

Abstract The safety and stability of high-speed maglev trains traveling on viaducts in crosswinds critically depend on their aerodynamic characteristics. Therefore, this paper uses an improved delayed detached eddy simulation (IDDES) method to investigate the aerodynamic features of high-speed maglev trains with different marshaling lengths under crosswinds. The effects of marshaling lengths (varying from 3-car to 8-car groups) on the train’s aerodynamic performance, surface pressure, and the flow field surrounding the train were investigated using the three-dimensional unsteady compressible Navier-Stokes (N-S) equations. The results showed that the marshaling lengths had minimal influence on the aerodynamic performance of the head and middle… More > Graphic Abstract

Tianyi Li^1,2, Xin Gu², Qing Zhang^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 339-361, 2024, DOI:10.32604/cmes.2024.047566

Abstract This study proposes a comprehensive, coupled thermomechanical model that replaces local spatial derivatives in classical differential thermomechanical equations with nonlocal integral forms derived from the peridynamic differential operator (PDDO), eliminating the need for calibration procedures. The model employs a multi-rate explicit time integration scheme to handle varying time scales in multi-physics systems. Through simulations conducted on granite and ceramic materials, this model demonstrates its effectiveness. It successfully simulates thermal damage behavior in granite arising from incompatible mineral expansion and accurately calculates thermal crack propagation in ceramic slabs during quenching. To account for material heterogeneity, the model utilizes the Shuffle algorithm… More >

FATMA LOUZRI, SADJIA BENNOUR

Journal of Polymer Materials, Vol.37, No.1-2, pp. 55-76, 2020, DOI:10.32381/JPM.2020.37.1-2.5

Abstract Poly(N,N-dimethymethylacrylamide -co-crotonic acid) (P(DMA-CAx)) hydrogels were prepared by free radical polymerization, using N,N- methylenebisacrylamide (NMBA) as cross-linking agent. The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). The effects of comonomer composition and pH of the medium on the swelling behavior of hydrogels were investigated. The obtained results showed that the swelling capabilities of hydrogels increased as crotonic acid content and pH increased. In order to evaluate the controlled release potential of the polymeric matrix, it was loaded with potassium nitrate and ammonium nitrate as fertilizers and the release kinetics was studied as a… More >

ASIS K. MANDAL¹, DEBABRATA CHAKRABORTY², MAHUYA DAS³, SAMIR K SIDDHANTA^4,*

Journal of Polymer Materials, Vol.38, No.1-2, pp. 21-34, 2021, DOI:10.32381/JPM.2021.38.1-2.3

Abstract Elastomeric chlorosulfonated polyethylene (Hypalon) and thermoplastic polypropylene (PP) based thermoplastic Vulcanizates (TPVs) were prepared in presence of different doses of partial methyl ester of styrene-maleic anhydride copolymer (PMES-MA) as compatibilizer employing dynamic vulcanization technique. The mechanical analysis of the prepared TPVs exhibited significant improvements in stress at 25% modulus, ultimate tensile strength (UTS), and hardness values. FTIR studies revealed that a chemical interaction had taken place between hypalon and compatibilizer during the process of dynamic vulcanization which led to an enhancement of interfacial adhesion between them. The two-phase morphologies were clearly observed by scanning electron microscopic studies. The Tg values… More >

Anastasia Bushueva, Olga Vlasova, Denis Polezhaev^*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 847-857, 2024, DOI:10.32604/fdmp.2024.048271

Abstract The steady flow in a Hele-Shaw cell filled with fluids with a high viscosity contrast in the presence of fluid oscillations is experimentally studied. The control of oscillatory dynamics of multiphase systems with interfaces is a challenging technological problem. We consider miscible (water and glycerol) and immiscible (water and high-viscosity silicone oil PMS-1000) fluids under subsonic oscillations perpendicular to the interface. Observations show that the interface shape depends on the amplitude and frequency of oscillations. The interface is undisturbed only in the absence of oscillations. Under small amplitudes, the interface between water and glycerol widens due to mixing. When the… More >

Mariya Shiryaeva¹, Mariya Subbotina², Stanislav Subbotin^1,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 787-802, 2024, DOI:10.32604/fdmp.2024.048165

Abstract This work is devoted to the experimental study of inertial wave regimes in a non-uniform rotating cylinder with antiparallel inclined ends. In this setting, the cross-section of the cylinder is divided into two regions where the fluid depth increases or decreases with radius. Three different regimes are found: inertial wave attractor, global oscillations (the cavity’s resonant modes) and regime of symmetric reflection of wave beams. In linear wave regimes, a steady single vortex elongated along the rotation axis is generated. The location of the wave’s interaction with the sloping ends determines the vortex position and the vorticity sign. In non-linear… More >