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  • Open Access


    Review on marine collagen peptides induce cancer cell apoptosis, necrosis, and autophagy by reducing oxidized free radicals


    BIOCELL, Vol.47, No.5, pp. 965-975, 2023, DOI:10.32604/biocell.2023.027729

    Abstract Marine collagen peptides (MCPs) are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes. MCPs have a range of structures and biological activities and are widely present in marine species. MCPs also have a small molecular weight, are easily modified, and absorbed by the body. These properties have attracted great interest from researchers studying antioxidant, anti-tumor, and anti-aging activities. MCPs of specific molecular weights have significant anti-tumor activity and no toxic side effects. Thus, MCPs have the potential use as anti-cancer adjuvant drugs. Free radicals produced by oxidation More >

  • Open Access


    Analysis of Antioxidant Potential of Trigonella foenum-graecum (L.) Extract Against Tumorigenesis

    Shivangi Goyal, Sreemoyee Chatterjee, Nidhi Gupta*

    Oncologie, Vol.23, No.1, pp. 89-104, 2021, DOI:10.32604/Oncologie.2021.015234

    Abstract Background: Trigonella foenum-graecum Linn. has been extensively used for medicinal purposes. The current study deals with in vitro and in vivo correlation of free radical quenching activity and anticancer potential of seed extracts of Trigonella. Materials and methods: Antioxidant activity was evaluated against DPPH, NO and ABTS via in vitro radical scavenging assay. Cytotoxicity effect of Trigonella seed extract was studied in human embryonic kidney HEK 293 cell line by alamar blue assay. In vivo antioxidant activity in Swiss albino mice model was assessed by studying endogenous antioxidant enzymes such as GSH, GPx, SOD and LPO. Antitumor effect was observed by studying parameters… More >

  • Open Access


    Alcohol hangover: impairments in behavior and bioenergetics in central nervous system

    Analia G. Karadayian1, Juanita Bustamante2, Silvia Lores-Arnaiz1, *

    BIOCELL, Vol.40, No.1, pp. 31-34, 2016, DOI:10.32604/biocell.2016.40.031

    Abstract Alcohol hangover (AH) is defined as the temporary state after alcohol binge-like drinking, starting when EtOH is absent in plasma. Results from our laboratory have shown behavioral impairments and mitochondrial dysfunction in an experimental model of AH in mice. Our model consisted in a single i.p. injection of EtOH (3.8 g/kg BW) or saline solution in male and female mice, sacrificing the animals 6 hours after injection. Motor and affective behavior together with mitochondrial function and free radical production were evaluated in brain cortex and cerebellum during AH. Results showed that hangover animals exhibited a… More >

  • Open Access


    Potential antioxidant and toxicological activity of the essential oil of Rhaphiodon echinus (Nees & Mart) Schauer (Lamiaceae): morphoanatomy and polyphenolic composition of its extracts

    Rodrigues Costa A1,2, PS Pereira3, MK Alves de Sousa1,2, FC Rodrigues5, VR Duarte Mendes1, KR Rodrigues Lima1, L Marivando Barros1,4, CM Rocha Sousa1, MS Alcântara1, AB Leite Cavalcante4, R Cruz Macedo5, JP Kamdem3, AE Duarte1,2

    Phyton-International Journal of Experimental Botany, Vol.87, pp. 79-86, 2018, DOI:10.32604/phyton.2018.87.079

    Abstract The species Rhaphiodon echinus, known as betonica or creeping mint, is considered an infesting plant species, typical of the caatinga biome. Morphoanatomy is a very important tool to study the structure of plants, both its external and internal morphology, opening the knowledge about the production of secondary metabolites. These compounds are of great importance for scientific research, which may present themselves as the best antioxidants. Taking into account a lack of data in the literature on the essential oil of R. echinus, this study aimed to demonstrate its antioxidant activity and toxicity. In order to test this… More >

  • Open Access


    Active compounds of medicinal plants, mechanism for antioxidant and beneficial effects

    Orozco Montes F1, A Vázquez-Hernández2, B Fenton-Navarro1

    Phyton-International Journal of Experimental Botany, Vol.88, No.1, pp. 1-10, 2019, DOI:10.32604/phyton.2019.04525

    Abstract An increased interest in the antioxidant effects of medicinal plants has developed in recent years. Identifying antioxidant compounds present in medicinal plants and elucidating the mechanism by which they prevent oxidation have been the focus of the research community. We performed a systematic and exhaustive review aimed at analyzing the available data regarding the beneficial effects of secondary metabolites in plants. The result of this review is presented as a description of free radicals, as well as cellular and physiological oxidative stress, is provided. The origin and source of antioxidant compounds, and the cellular and More >

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