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  • Open Access

    ARTICLE

    Ligand Based Virtual Screening of Molecular Compounds in Drug Discovery Using GCAN Fingerprint and Ensemble Machine Learning Algorithm

    R. Ani1,*, O. S. Deepa2, B. R. Manju1

    Computer Systems Science and Engineering, Vol.47, No.3, pp. 3033-3048, 2023, DOI:10.32604/csse.2023.033807

    Abstract The drug development process takes a long time since it requires sorting through a large number of inactive compounds from a large collection of compounds chosen for study and choosing just the most pertinent compounds that can bind to a disease protein. The use of virtual screening in pharmaceutical research is growing in popularity. During the early phases of medication research and development, it is crucial. Chemical compound searches are now more narrowly targeted. Because the databases contain more and more ligands, this method needs to be quick and exact. Neural network fingerprints were created more effectively than the well-known… More >

  • Open Access

    ARTICLE

    IPv6 Cryptographically Generated Address: Analysis, Optimization and Protection

    Amjed Sid Ahmed1,*, Rosilah Hassan2, Faizan Qamar3, Mazhar Malik1

    CMC-Computers, Materials & Continua, Vol.68, No.1, pp. 247-265, 2021, DOI:10.32604/cmc.2021.014233

    Abstract In networking, one major difficulty that nodes suffer from is the need for their addresses to be generated and verified without relying on a third party or public authorized servers. To resolve this issue, the use of self-certifying addresses have become a highly popular and standardized method, of which Cryptographically Generated Addresses (CGA) is a prime example. CGA was primarily designed to deter the theft of IPv6 addresses by binding the generated address to a public key to prove address ownership. Even though the CGA technique is highly effective, this method is still subject to several vulnerabilities with respect to… More >

  • Open Access

    REVIEW

    PGCA-Net: Progressively Aggregating Hierarchical Features with the Pyramid Guided Channel Attention for Saliency Detection

    Jiajie Mai1, Xuemiao Xu2,*, Guorong Xiao3, Zijun Deng2, Jiaxing Chen2

    Intelligent Automation & Soft Computing, Vol.26, No.4, pp. 847-855, 2020, DOI:10.32604/iasc.2020.010119

    Abstract The Salient object detection aims to segment out the most visually distinctive objects in an image, which is a challenging task in computer vision. In this paper, we present the PGCA-Net equipped with the pyramid guided channel attention fusion block (PGCAFB) for the saliency detection task. Given an input image, the hierarchical features are extracted using a deep convolutional neural network (DCNN), then starting from the highest-level semantic features, we stage-by-stage restore the spatial saliency details by aggregating the lowerlevel detailed features. Since for the weak discriminative ability of the shallow detailed features, directly introducing them to the semantic features… More >

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