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  • Open Access


    What is the role of apical ventriculotomy in children and young adults with hypertrophic cardiomyopathy?

    Alex J. Thompson1, Joseph A. Dearani2, Jonathan N. Johnson1,3, Hartzell V. Schaff2, Eric C. Towe1, Jared Palfreeman1, Philip L. Wackel1, Frank Cetta1,3

    Congenital Heart Disease, Vol.13, No.4, pp. 617-623, 2018, DOI:10.1111/chd.12618

    Abstract Background: The transapical approach has been utilized in adult HCM patients with either midventricular obstruction or a small LV cavity; however, there are little data on its use in children.
    Methods: We retrospectively reviewed all patients (age <21 years) with HCM who underwent a transapical myectomy from January 2002 to December 2016. Indication for surgery was midventricular obstruction in 19/23 (83%) and small LV cavity in 4 (17%). Preoperative symptoms included: dyspnea (96%), chest pain (65%), presyncope (61%), and syncope (35%). The mean age at the time of operation was 14 ± 4.0 years (range, 4–20).
    Results: Overall, 23 patients… More >

  • Open Access


    Numerical Simulation of Myocardial Bridging in Patients with Hypertrophic Cardiomyopathy

    Mohammadali Sharzehee1, Yuan Chang2, Jiang-ping Song2, Hai-Chao Han1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 16-17, 2019, DOI:10.32604/mcb.2019.07129

    Abstract A myocardial bridge (MB), a congenital anomaly of the coronary artery, occurs when a segment of the epicardial coronary artery goes underneath the myocardium. MBs are often observed in the middle part of the left anterior descending (LAD) artery. MB squeezes the vessel wall periodically and induces hemodynamic abnormalities which are correlated with angina and myocardial ischemia. The level of hemodynamics disturbances induced by MB depends on the myocardial bridge length, the degree of myocardial contractility, thickness, and location [1]. Hypertrophic cardiomyopathy (HCM), characterized by abnormal thickening of the heart wall, is a leading cause of death in patients of… More >

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