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    An Isogeometric Analysis Computational Platform for Material Transport Simulation in Complex Neurite Networks

    Angran Li1, Xiaoqi Chai2, Ge Yang2,3, Yongjie Jessica Zhang1,2,*

    Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 123-140, 2019, DOI:10.32604/mcb.2019.06479

    Abstract Neurons exhibit remarkably complex geometry in their neurite networks. So far, how materials are transported in the complex geometry for survival and function of neurons remains an unanswered question. Answering this question is fundamental to understanding the physiology and disease of neurons. Here, we have developed an isogeometric analysis (IGA) based platform for material transport simulation in neurite networks. We modeled the transport process by reaction-diffusion-transport equations and represented geometry of the networks using truncated hierarchical tricubic B-splines (THB-spline3D). We solved the Navier-Stokes equations to obtain the velocity field of material transport in the networks. More >

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