HUAQING MO#, JINGYI SHEN#, YUXIAO ZHONG, ZENAN CHEN, TONG WU, YANYU LV*, YANYAN XIE, YANRONG HAO*
Oncology Research, Vol.30, No.4, pp. 187-199, 2022, DOI:10.32604/or.2022.027534
Abstract Nasopharyngeal carcinoma (NPC) is the most prevalent human primary malignancy of the head and neck, and
the presence of vasculogenic mimicry (VM) renders anti-angiogenic therapy ineffective and poorly prognostic. However,
the underlying mechanisms are unclear. In the present study, we used miR-940 silencing and overexpression for in vitro
NPC cell EdU staining, wound healing assay and 3D cell culture assay, and in vivo xenograft mouse model and VM
formation to assess miR-940 function. We found that ectopic miR-940 expression reduced NPC cell proliferation,
migration and VM, as well as tumorigenesis in vivo. By bioinformatic analysis, circMAN1A2 was identified as a… More >
Login
Register
