QIAO ZHOU2,3,4, JIAN LIU1,2,*, LING XIN1, YANYAN FANG1,2, LEI WAN1,2, DAN HUANG1,2, JIANTING WEN1,2
BIOCELL, Vol.47, No.7, pp. 1623-1643, 2023, DOI:10.32604/biocell.2023.028331
Abstract Objective: On the basis of data mining, systematic pharmacology, molecular docking, and experiment
validation, the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis (OA) were
explored. Methods: The association rule analysis was effectively applied to highlight the correlation between Coicis
Semen and oxidative inflammation indices. The random walk model was subsequently used to evaluate the clinical
efficacy of Coicis Semen. Network pharmacology was used to predict network targets. The binding affinity of the
active ingredient in Coicis Semen to the key target of OA was also successfully predicted. Results: Coicis Semen
showed a significant reduction in oxidative-inflammatory… More >
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