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    A Novel Atlas-Based Strategy for Understanding Cardiac Dysfunction in Patients with Congenital Heart Disease

    Sara Salehyar1, †, Nickolas Forsch1,†,*, Kathleen Gilbert2,3, Alistair A. Young3,4, James C. Perry5, Sanjeet Hegde5, Jeffrey H. Omens1,6, Andrew D. McCulloch1,6

    Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 179-183, 2019, DOI:10.32604/mcb.2019.07384

    Abstract Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. Infants diagnosed with TOF require surgical interventions to survive into adulthood. However, as a result of postoperative structural malformations and long-term ventricular remodeling, further interventions are often required later in life. To help identify those at risk of disease progression, serial cardiac magnetic resonance (CMR) imaging is used to monitor these patients. However, most of the detailed information on cardiac shape and biomechanics contained in these large four-dimensional (4D) data sets goes unused in clinical practice for lack of efficient and comprehensive quantitative analysis tools. While… More >

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