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  • Open Access

    ARTICLE

    Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

    WEIXUE WANG#, TONGTONG WANG#, YAN ZHANG, TING DENG, HAIYANG ZHANG*, YI BA*

    Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

    Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

  • Open Access

    RETRACTION

    Retraction: Psychological Support for Public-Funded Normal Students Engaged in Teaching Profession

    Shize Zhi1,2,*

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 81-81, 2024, DOI:10.32604/ijmhp.2024.049077

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Associations of Domain and Pattern of Sedentary Behaviors with Symptoms of Mental Disorders in Saudi Adults: ‘The Sedentary Behavior Paradox’

    Abdullah B. Alansare*

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 11-20, 2024, DOI:10.32604/ijmhp.2023.044656

    Abstract Emerging evidence suggests the existence of ‘paradoxical’ relationships between domain-specific sedentary behavior (SB) and health outcomes. This study assessed the associations of total and domain-specific SB, by pattern, with symptoms of mental disorders in Saudi adults. Participants (n = 554) completed a web-based survey between January 18th, 2023 and February 5th, 2023. Total SB was measured by using the Sedentary Behavior Questionnaire. Total SB was then partitioned into leisure, occupational, and commuting SB during weekdays and on weekend days. Symptoms of mental disorders including symptoms of depression, anxiety, and stress were evaluated by using the DASS-21 questionnaire. Adjusted linear regressions… More >

  • Open Access

    ARTICLE

    Internet Use and Mental Health among Older Adults in China: Beneficial for Those Who Lack of Intergenerational Emotional Support or Suffering from Chronic Diseases?

    Yuxin Wang1,2,*, Jia Shi1,2

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 69-80, 2024, DOI:10.32604/ijmhp.2023.044641

    Abstract In the 21st century, the rapid growth of the Internet has presented a significant avenue for China to respond actively to the aging population and promote the “Healthy China” strategy in an orderly manner. This study uses panel data from the China Health and Retirement Longitudinal Study (CHARLS) to empirically investigate the influence of Internet use on the mental health of older adults, particularly those who lack intergenerational emotional support and suffer from chronic diseases. This study employs a multi-period difference-in-differences (DID) method and a two-stage instrumental variable approach to address the endogenous problem. Results show that Internet use has… More >

  • Open Access

    ARTICLE

    Meiotic nuclear divisions 1 suppresses the proliferation and invasion of pancreatic cancer cells via regulating H2A.X variant histone

    DONGQIN WANG1,4, YAN SHI1, ZHIQIANG WANG4, JING ZHANG2, LUYAO WANG2, HONGYU MA3, SHUHUA SHI2, XIAOFU LIAN2, HUA HUANG4, XIAOJING WANG1,*, CHAOQUN LIAN4,*

    BIOCELL, Vol.48, No.1, pp. 111-122, 2024, DOI:10.32604/biocell.2023.046903

    Abstract Introduction: Among all malignant tumors of the digestive system, pancreatic carcinoma exhibits the highest mortality rate. Currently, prevention and effective treatment are urgent issues that need to be addressed. Methods: The study focused on meiotic nuclear divisions 1 (MND1), integrating data from the Gene Expression Profiling Interactive Analysis (GEPIA) database with prognostic survival analysis. Simultaneously, experiments at cellular level were employed to demonstrate the effect of MND1 on the proliferation and migration of PC. The small-molecule inhibitor of MND1 was used to suppress the migration of PC cells by knocking down MND1 using small interfering RNA (siRNA) in Patu-8988 and… More >

  • Open Access

    ARTICLE

    An Assisted Diagnosis of Alzheimer’s Disease Incorporating Attention Mechanisms Med-3D Transfer Modeling

    Yanmei Li1,*, Jinghong Tang1, Weiwu Ding1, Jian Luo2, Naveed Ahmad3, Rajesh Kumar4

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 713-733, 2024, DOI:10.32604/cmc.2023.046872

    Abstract Alzheimer’s disease (AD) is a complex, progressive neurodegenerative disorder. The subtle and insidious onset of its pathogenesis makes early detection of a formidable challenge in both contemporary neuroscience and clinical practice. In this study, we introduce an advanced diagnostic methodology rooted in the Med-3D transfer model and enhanced with an attention mechanism. We aim to improve the precision of AD diagnosis and facilitate its early identification. Initially, we employ a spatial normalization technique to address challenges like clarity degradation and unsaturation, which are commonly observed in imaging datasets. Subsequently, an attention mechanism is incorporated to selectively focus on the salient… More >

  • Open Access

    ARTICLE

    Improving Video Watermarking through Galois Field GF(24) Multiplication Tables with Diverse Irreducible Polynomials and Adaptive Techniques

    Yasmin Alaa Hassan1,*, Abdul Monem S. Rahma2

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1423-1442, 2024, DOI:10.32604/cmc.2023.046149

    Abstract Video watermarking plays a crucial role in protecting intellectual property rights and ensuring content authenticity. This study delves into the integration of Galois Field (GF) multiplication tables, especially GF(24), and their interaction with distinct irreducible polynomials. The primary aim is to enhance watermarking techniques for achieving imperceptibility, robustness, and efficient execution time. The research employs scene selection and adaptive thresholding techniques to streamline the watermarking process. Scene selection is used strategically to embed watermarks in the most vital frames of the video, while adaptive thresholding methods ensure that the watermarking process adheres to imperceptibility criteria, maintaining the video’s visual quality.… More >

  • Open Access

    ARTICLE

    ProNet Adaptive Retinal Vessel Segmentation Algorithm Based on Improved UperNet Network

    Sijia Zhu1,*, Pinxiu Wang2, Ke Shen1

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 283-302, 2024, DOI:10.32604/cmc.2023.045506

    Abstract This paper proposes a new network structure, namely the ProNet network. Retinal medical image segmentation can help clinical diagnosis of related eye diseases and is essential for subsequent rational treatment. The baseline model of the ProNet network is UperNet (Unified perceptual parsing Network), and the backbone network is ConvNext (Convolutional Network). A network structure based on depth-separable convolution and 1 × 1 convolution is used, which has good performance and robustness. We further optimise ProNet mainly in two aspects. One is data enhancement using increased noise and slight angle rotation, which can significantly increase the diversity of data and help… More >

  • Open Access

    ARTICLE

    Network Intrusion Traffic Detection Based on Feature Extraction

    Xuecheng Yu1, Yan Huang2, Yu Zhang1, Mingyang Song1, Zhenhong Jia1,3,*

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 473-492, 2024, DOI:10.32604/cmc.2023.044999

    Abstract With the increasing dimensionality of network traffic, extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems (IDS). However, both unsupervised and semisupervised anomalous traffic detection methods suffer from the drawback of ignoring potential correlations between features, resulting in an analysis that is not an optimal set. Therefore, in order to extract more representative traffic features as well as to improve the accuracy of traffic identification, this paper proposes a feature dimensionality reduction method combining principal component analysis and Hotelling’s T2 and a multilayer convolutional bidirectional long short-term memory (MSC_BiLSTM)… More >

  • Open Access

    ARTICLE

    Using MsfNet to Predict the ISUP Grade of Renal Clear Cell Carcinoma in Digital Pathology Images

    Kun Yang1,2,3, Shilong Chang1, Yucheng Wang1, Minghui Wang1, Jiahui Yang1, Shuang Liu1,2,3, Kun Liu1,2,3, Linyan Xue1,2,3,*

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 393-410, 2024, DOI:10.32604/cmc.2023.044994

    Abstract Clear cell renal cell carcinoma (ccRCC) represents the most frequent form of renal cell carcinoma (RCC), and accurate International Society of Urological Pathology (ISUP) grading is crucial for prognosis and treatment selection. This study presents a new deep network called Multi-scale Fusion Network (MsfNet), which aims to enhance the automatic ISUP grade of ccRCC with digital histopathology pathology images. The MsfNet overcomes the limitations of traditional ResNet50 by multi-scale information fusion and dynamic allocation of channel quantity. The model was trained and tested using 90 Hematoxylin and Eosin (H&E) stained whole slide images (WSIs), which were all cropped into 320… More >

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