Jiaojiao Wu^1,#, Dou Fu^2,#, Lili Zhang^1,*, Xiangying Xie³, Xinmei Wang², Xiangying Shen¹, Shanshan Liu², Xu Xu⁴, Hui Cheng⁵, Xiaojie Ma¹, Doudou Lin¹

International Journal of Mental Health Promotion, Vol.26, No.11, pp. 897-904, 2024, DOI:10.32604/ijmhp.2024.056223 - 28 November 2024

Abstract Background: With the rapid aging of China’s population and the increasing prevalence of comorbidities in the elderly, psychological crises have become more common. This study aims to investigate the present status of psychological vulnerability, aging attitudes, and life meaning in elderly patients with comorbidities. Methods: A total of 685 elderly inpatients and outpatients at Renmin Hospital of Wuhan University between July and December 2022 were selected using the simple random sampling method. Social demographic data were collected, and the Attitudes to aging Questionnaire (AAQ), the Chinese Life Meaning Questionnaire (C-MLQ), and the Psychological Vulnerability Scale… More >

DIEGO HERNANDEZ^1,*, CHIH-YUAN CHENG^1,2, KARLA HERNANDEZ-VILLAFUERTE¹, MICHAEL SCHLANDER^1,2

Oncology Research, Vol.30, No.4, pp. 173-185, 2022, DOI:10.32604/or.2022.027262 - 31 January 2023

Abstract Lung cancer is the most common cancer type worldwide and has the highest and second highest mortality rate for men and women respectively in Germany. Yet, the role of comorbid illnesses in lung cancer patient prognosis is still debated. We analyzed administrative claims data from one of the largest statutory health insurance (SHI) funds in Germany, covering close to 9 million people (11% of the national population); observation period was from 2005 to 2019. Lung cancer patients and their concomitant diseases were identified by ICD-10-GM codes. Comorbidities were classified according to the Charlson Comorbidity Index… More >

Shuna Peng¹, Xiaohong Luo¹, Shiyu Liang¹, Fengning Deng¹, Yuning Liu², Hong Zeng^1,*, Xuesong Yang^3,*

International Journal of Mental Health Promotion, Vol.24, No.5, pp. 711-724, 2022, DOI:10.32604/ijmhp.2022.020556 - 27 July 2022

Abstract Background: The coronavirus (COVID-19) outbreak in 2019 triggered psychological and emotional responses. This research investigates the psychological status and emotional problems of those who sought psychological assistance during the epidemic period by calling a mental health hotline. Methods: This study aims to combine qualitative and quantitative research. Descriptive analysis was used for undertaking qualitative research. We analyzed the data from group 1 (n = 706), in which the people used the mental health hotline from 25 January 2020 to 23 June 2020. A self-designed questionnaire was developed in accordance with the classification and summarized items… More >

KATARINA BARALIć^1,*, KATARINA ŽIVANčEVIć¹, DRAGICA BoŽIĆ¹, DANYEL JENNEN², ALEKSANDRA BUHA DJORDJEVIC¹, EVICA ANTONIJEVIć MILJAKOVIć¹, DANIJELA ĐUKIć-ĆOSIć¹

BIOCELL, Vol.46, No.2, pp. 519-533, 2022, DOI:10.32604/biocell.2022.018271 - 20 October 2021

Abstract This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www.disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194… More >

E. David Crawford¹, Andrew V. Schally²

Canadian Journal of Urology, Vol.27, No.2, pp. 10167-10173, 2020

Abstract Introduction: In this article we advance a potential explanation for the incidence of cardiovascular (CV) and cardiometabolic risk in patients undergoing androgen deprivation therapy (ADT) for prostate cancer. Our conceptual model involves the differential impact of gonadotropin-releasing hormone (GnRH) agonists and antagonists on the follicle-stimulating hormone (FSH) system.
Materials and methods: Authors searched online repositories and meeting abstract databases for relevant materials.
Results: Mounting evidence links FSH with development and progression of prostate cancer. What is also becoming clear is that the differential effects of GnRH agonists and antagonists on FSH may at least partially explain the differing… More >

Uzoma A. Anele¹, Robert L. Segal^1,2, Brian V. Le¹, Arthur L. Burnett¹

Canadian Journal of Urology, Vol.21, No.6, pp. 7554-7559, 2014

Abstract Introduction: Penile prosthesis implantation (PPI) is the definitive surgical treatment for erectile dysfunction (ED), yet it is often delayed for a variety of reasons. From commercial and Medicare claims data, we previously developed a tool for determining a patient’s likelihood of eventually receiving PPI. We validated this instrument’s utility by comparing cohorts receiving surgical (PPI) versus non-surgical ED management at a single institution.
Material and methods: The prediction model was based on a logistic regression incorporating claims data on demographics, comorbidities and ED therapy. A risk score is calculated from the model as the product of relative… More >

John-Paul McCarthy, Thomas A. A. Skinner, Richard W. Norman

Canadian Journal of Urology, Vol.18, No.3, pp. 5717-5720, 2011

Abstract Objectives: Urolithiasis is an increasing problem among patients aged 80 years and older. Our objective was to compare patients aged ≥ 80 years with a younger cohort in terms of presentation and management of urolithiasis.
Methods: Patients referred to a tertiary care stone clinic for the management of urolithiasis over a 5-year period were reviewed. Clinical data from patients aged ≥ 80 years were compared with a random sample of those under 80 years.
Results: There were 26 patients aged ≥ 80 years and 102 patients in the younger cohort; mean ages were 83.5 ± 0.6 and 50.1… More >