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  • Open Access


    Applications of CRISPR-Cas System in Tumor Biology

    Mengdan Ma1,2, Yuchen Liu1,*, Weiren Huang1,*

    Oncologie, Vol.23, No.4, pp. 463-492, 2021, DOI:10.32604/oncologie.2022.019415

    Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals. This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the genetic components of a system has led to various practical applications, such… More >

  • Open Access


    A Numerical Study on the Mechanisms Producing Forces on Cylinders Interacting with Stratified Shear Environments

    Yin Wang1,*, Lingling Wang2, Yong Ji1, Zhicheng Xi1, Wenwen Zhang1

    FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.2, pp. 471-485, 2021, DOI:10.32604/fdmp.2021.014652

    Abstract A three dimensional (3D) numerical wave flume is used to investigate carefully the ISWs (Internal solitary wave) forces acting on cylinders interacting with a stratified shear environment. Using the Large-Eddy Simulation (LES) approach and analyzing the distribution of shear stress and pressure along the surface of the cylinder, the differential pressure resistance and the viscous force are obtained. The method of multiple linear regression analysis is adopted and a comprehensive influence coefficient is determined accordingly to account for the dimensionless forces acting on the cylinder. Results show that the differential pressure resistance on a square More >

  • Open Access

    Anisometry Anterior Cruciate Ligament Sport Injury Mechanism Study: A Finite Element Model with Optimization Method

    Na Li*, Wei Wang*, Bin Ye*, Song Wu†,‡

    Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 87-100, 2014, DOI:10.3970/mcb.2014.011.087

    Abstract ACL damage is one the most frequent causes of knee injuries and thus has long been the focus of research in biomechanics and sports medicine. Due to the anisometric geometry and functional complexity of the ACL in the knee joint, it is usually difficult to experimentally study the biomechanics of ACLs. Anatomically ACL geometry was obtained from both MR images and anatomical observations. The optimal material parameters of the ACL were obtained by using an optimization-based material identification method that minimized the differences between experimental results from ACL specimens and FE simulations. The optimal FE… More >

  • Open Access


    Mechanism study of TiO2 nanowire tensile behaviors via molecular dynamics simulations

    L. Dai1, V.B.C. Tan1,2, C.H. Sow1,3, C.T. Lim1,2,4, W.C.D. Cheong5

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 151-162, 2009, DOI:10.3970/icces.2009.009.151

    Abstract The mechanisms governing the tensile response of TiO2 nanowires were studied by molecular dynamics simulations. The free side surfaces of the nanowires were found to be undulating because atoms near the free surface were relaxed into a disordered state during thermodynamic equilibration. For wires below a threshold diameter of around 10 Å, this free surface effect extends throughout the entire wire, resulting in a complete lack of ordered structure. For thick nanowires, the core of the wire retains a crystalline structure. The thicker the wire, the larger the crystalline core and the more dominant is its More >

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