Mengdan Ma^1,2, Yuchen Liu^1,*, Weiren Huang^1,*

Oncologie, Vol.23, No.4, pp. 463-492, 2021, DOI:10.32604/oncologie.2022.019415

Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals. This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the genetic components of a system has led to various practical applications, such as base editing, transcription regulation,… More >

Yin Wang^1,*, Lingling Wang², Yong Ji¹, Zhicheng Xi¹, Wenwen Zhang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.2, pp. 471-485, 2021, DOI:10.32604/fdmp.2021.014652

Abstract A three dimensional (3D) numerical wave flume is used to investigate carefully the ISWs (Internal solitary wave) forces acting on cylinders interacting with a stratified shear environment. Using the Large-Eddy Simulation (LES) approach and analyzing the distribution of shear stress and pressure along the surface of the cylinder, the differential pressure resistance and the viscous force are obtained. The method of multiple linear regression analysis is adopted and a comprehensive influence coefficient is determined accordingly to account for the dimensionless forces acting on the cylinder. Results show that the differential pressure resistance on a square cylinder is 1.5 times higher… More >

Na Li*, Wei Wang*, Bin Ye*, Song Wu^†,‡

Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 87-100, 2014, DOI:10.3970/mcb.2014.011.087

Abstract ACL damage is one the most frequent causes of knee injuries and thus has long been the focus of research in biomechanics and sports medicine. Due to the anisometric geometry and functional complexity of the ACL in the knee joint, it is usually difficult to experimentally study the biomechanics of ACLs. Anatomically ACL geometry was obtained from both MR images and anatomical observations. The optimal material parameters of the ACL were obtained by using an optimization-based material identification method that minimized the differences between experimental results from ACL specimens and FE simulations. The optimal FE model simulated biomechanical responses of… More >

L. Dai¹, V.B.C. Tan^1,2, C.H. Sow^1,3, C.T. Lim^1,2,4, W.C.D. Cheong⁵

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 151-162, 2009, DOI:10.3970/icces.2009.009.151

Abstract The mechanisms governing the tensile response of TiO₂ nanowires were studied by molecular dynamics simulations. The free side surfaces of the nanowires were found to be undulating because atoms near the free surface were relaxed into a disordered state during thermodynamic equilibration. For wires below a threshold diameter of around 10 Å, this free surface effect extends throughout the entire wire, resulting in a complete lack of ordered structure. For thick nanowires, the core of the wire retains a crystalline structure. The thicker the wire, the larger the crystalline core and the more dominant is its effect on the tensile… More >