Dandan Wu^*1, Jun Liu^†1, Jianliang Chen^*, Haiyan He^*, Hang Ma^*, Xuedong Lv^*

Oncology Research, Vol.27, No.2, pp. 227-235, 2019, DOI:10.3727/096504018X15213089759999

Abstract MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The dysregulation of miR-449a is found in many types of malignancies and is associated with tumor growth, migration, and invasion. However, its expression and function in non-small cell lung cancer (NSCLC) still remains unclear. In our study, miR-449a was found to be downregulated in both NSCLC tissues and cell lines, and low miR-449a expression was obviously associated with tumor differentiation, TMN stage, and poor overall survival (OS). Moreover, we demonstrated that miR-449a could inhibit tumor proliferation, migration, and invasion in More >

Yosuke Mitsui^*†, Nahoko Tomonobu^*, Masami Watanabe^†, Rie Kinoshita^*, I Wayan Sumardika^*‡, Chen Youyi^*, Hitoshi Murata^*, Ken-ichi Yamamoto^*, Takuya Sadahira^†, Acosta Gonzalez Herik Rodrigo^*†, Hitoshi Takamatsu^*, Kota Araki^*§, Akira Yamauchi^¶, Masahiro Yamamura^#, Hideyo Fujiwara^**, Yusuke Inoue^††, Junichiro Futami^‡‡, Ken Saito^§§, Hidekazu Iioka^§§, Eisaku Kondo^§§, Masahiro Nishibori^¶¶, Shinichi Toyooka^§, Yasuhiko Yamamoto^##, Yasutomo Nasu^†, Masakiyo Sakaguchi^*

Oncology Research, Vol.27, No.8, pp. 945-956, 2019, DOI:10.3727/096504019X15555408784978

Abstract S100A11, a member of the S100 family of proteins, is actively secreted from pancreatic ductal adenocarcinoma (PDAC) cells. However, the role of the extracellular S100A11 in PDAC progression remains unclear. In the present study, we investigated the extracellular role of S100A11 in crosstalking between PDAC cells and surrounding fibroblasts in PDAC progression. An abundant S100A11 secreted from pancreatic cancer cells stimulated neighboring fibroblasts through receptor for advanced glycation end products (RAGE) upon S100A11 binding and was followed by not only an enhanced cancer cell motility in vitro but also an increased number of the PDAC-derived… More >

Honghao Gao^{1, 2, 5}, Wanqiu Huang^{1, 4}, Xiaoxian Yang³

Intelligent Automation & Soft Computing, Vol.25, No.3, pp. 547-559, 2019, DOI:10.31209/2019.100000110

Abstract Path planning is an important topic of research in modern intelligent traffic systems (ITSs). Traditional path planning methods aim to identify the shortest path and recommend this path to the user. However, the shortest path is not always optimal, especially in emergency rescue scenarios. Thus, complex and changeable factors, such as traffic congestion, road construction and traffic accidents, should be considered when planning paths. To address this consideration, the maximum passing probability of a road is considered the optimal condition for path recommendation. In this paper, the traffic network is abstracted as a directed graph.… More >

Jiachen Wei^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 103-104, 2019, DOI:10.32604/mcb.2019.07721

Abstract Phoretic flow can be generated by different types of gradient (e.g. temperature, concentration, or charge gradient) [1-3]. Within micro-to-nano confined system, the diffusio-phoretic property for proteins differs dramatically from that obtained in bulk condition, due to concentration fluctuation that emerges at microscopic level induced by specific and nonspecific interactions between protein and co-solute [4-5]. The phoretic mobility of protein individuals and complex in solute gradients can be theoretically described by continuum model [1-2] that neglects microscopic heterogeneity and determined experimentally by microfluidics [6], but the underlying mechanism of diffusio-phoretic motion for confined protein still remains… More >

Swapan K Pati

The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.4, pp. 180-180, 2019, DOI:10.32604/icces.2019.05545

Abstract In recent years, many van der Waals solids, perovskites, spinels etc. exhibit many fold benefits for applications in a number of fields, namely, transparent substrates, field effect transistors, solar cells, thermoelectric materials, active surface for catalysis, rechargeable battery etc, to name a few. In fact, recent experimental advancements on the control over the surface structure of materials has enabled material scientists to tailor the material properties with improved reliability and functionality. We have derived relaxation time formulation from complete Boltzmann transport equation and obtained all the parameters from ab-initio density functional theory. Using this formalism,… More >

Meihua Liu¹, Xinchen Zhang^2,*, Shuangkui Ge³, Xiaoli Chen¹, Jianbin Wu², Mao Tian¹

CMC-Computers, Materials & Continua, Vol.60, No.2, pp. 559-574, 2019, DOI:10.32604/cmc.2019.04843

Abstract In Opportunistic networks (ONs), buffer management is critical to improve the message exchanging efficiency due to the limited storage space and transmission bandwidth at the wireless edge. Current solutions make message scheduling and drop policy based on assumptions that messages can always been forwarded in a single contact, and all node pairs have the same contact rates. However, such ideal assumptions are invalid for realistic mobility traces of hand-held. Recent studies show that the single contact duration is limited and the mobility of nodes is heterogeneous in reality. In this paper, a buffer management strategy… More >

Zhiqiang Liu^*1, Qiang Li^*1, Xin Zhao^†, Bin Cui^*, Libo Zhang^*, Qiang Wang^*

Oncology Research, Vol.26, No.9, pp. 1439-1446, 2018, DOI:10.3727/096504018X15189093975640

Abstract Numerous studies have suggested that microRNAs (miRNAs) are dysregulated in osteosarcoma (OS), implicating miRNAs in OS initiation and progression. Therefore, knowledge of aberrantly expressed miRNAs in OS may provide novel mechanistic insights into the tumorigenesis and tumor development of OS and facilitate therapeutic methods for patients with this aggressive bone neoplasm. In this study, data obtained from reverse transcription quantitative polymerase chain reaction (RT-qPCR) revealed that miR-935 was significantly decreased in OS tissues and cell lines. Restoration expression of miR-935 obviously restricted proliferation and invasion of OS cells. In addition, high-mobility group box 1 (HMGB1)… More >

Pengwei Lu, Yuanting Gu, Lin Li, Fang Wang, Xue Yang, Yunqing Yang

Oncology Research, Vol.26, No.4, pp. 625-635, 2018, DOI:10.3727/096504017X14953948675395

Abstract Breast cancer is a serious threat to women’s physical and psychological health. Long noncoding RNA CAMTA1 (lncCAMTA1) was believed to be related with tumor progression, but its role in breast cancer is not clear. The human breast cancer cell line MDA-MB-231 was used to investigate the effect of lncCAMTA1 on cell viability, migration/invasion, and apoptosis. The expression of lncCAMTA1, miR-20b, and VEGF in MDAMB-231 were measured after corresponding transfections. Binding effects between lncCAMTA1 and miR-20b, miR-20b, and VEGF 3'-UTR were measured. The effects of miR-20b and VEGF on breast cancer cells were also assessed after… More >

Dandan Li^*, Changjun He^†, Junfeng Wang^†, Yanbo Wang^†, Jianlong Bu^†, Xianglong Kong^†, Dawei Sun^†

Oncology Research, Vol.26, No.3, pp. 385-400, 2018, DOI:10.3727/096504017X14973124850905

Abstract Many studies have shown that downregulation of miR-138 occurs in a variety of cancers including non-small cell lung cancer (NSCLC). However, the precise mechanisms of miR-138 in NSCLC have not been well clarified. In this study, we investigated the biological functions and molecular mechanisms of miR-138 in NSCLC cell lines, discussing whether it could turn out to be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is downregulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression of SOX4 in… More >

Yidong Cao^*1, Liang Zhang^*1, Minghao Wei^*, Xue Jiang^†, Dong Jia^*

Oncology Research, Vol.25, No.7, pp. 1097-1107, 2017, DOI:10.3727/096504017X14836170586829

Abstract Emerging evidence has suggested that aberrantly expressed microRNAs (miRNAs) are associated with glioma development and progression. The aberrant expression of miR-409-3p has been reported in several human cancers. However, little is known about the function of miR-409-3p in gliomas. The aim of this study was to investigate the specific role and molecular mechanism of miR-409-3p in gliomas. In the present study, we found that miR-409-3p was downregulated in glioma tissue and cell lines. Overexpression of miR-409-3p inhibited glioma cell invasion and proliferation, whereas suppression of miR-409-3p promoted glioma cell invasion and proliferation. High-mobility group nucleosome-binding More >