Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Jing Cai^1,#, Haoyun Zhu^1,#, Weiling Guo¹, Ting Huang¹, Pangzhou Chen^1,2, Wen Zhou¹, Ziyun Guan^1,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069902 - 30 December 2025

Abstract Background: Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity. Current preclinical models, however, are inadequate for predicting individual patient responses towards different drugs. This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations. Methods: Tumor and adjacent tissues from female breast cancer patients were collected during surgery. Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models. The obtained patient-derived conditional reprogramming breast cancer (CRBC) cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres… More >

Lino Gonzalez-Garcia^*, Miguel-Angel Sicilia, Elena García-Barriocanal

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-15, 2026, DOI:10.32604/cmc.2025.070813 - 09 December 2025

Abstract Classifying job offers into occupational categories is a fundamental task in human resource information systems, as it improves and streamlines indexing, search, and matching between openings and job seekers. Comprehensive occupational databases such as NET or ESCO provide detailed taxonomies of interrelated positions that can be leveraged to align the textual content of postings with occupational categories, thereby facilitating standardization, cross-system interoperability, and access to metadata for each occupation (e.g., tasks, knowledge, skills, and abilities). In this work, we explore the effectiveness of fine-tuning existing language models (LMs) to classify job offers with occupational descriptors… More >

Yaxin Zhao¹, Qi Han², Hui Shu², Yan Guang^2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-24, 2026, DOI:10.32604/cmc.2025.070511 - 09 December 2025

Abstract Large Language Models (LLMs) are increasingly applied in the field of code translation. However, existing evaluation methodologies suffer from two major limitations: (1) the high overlap between test data and pretraining corpora, which introduces significant bias in performance evaluation; and (2) mainstream metrics focus primarily on surface-level accuracy, failing to uncover the underlying factors that constrain model capabilities. To address these issues, this paper presents TCode (Translation-Oriented Code Evaluation benchmark)—a complexity-controllable, contamination-free benchmark dataset for code translation—alongside a dedicated static feature sensitivity evaluation framework. The dataset is carefully designed to control complexity along multiple dimensions—including syntactic… More >

Himadri Nath Saha¹, Dipanwita Chakraborty Bhattacharya^2,*, Sancharita Dutta³, Arnab Bera³, Srutorshi Basuray⁴, Satyasaran Changdar⁵, Saptarshi Banerjee⁶, Jon Turdiev⁷

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-56, 2026, DOI:10.32604/cmc.2025.070507 - 09 December 2025

Abstract The emergence of Medical Large Language Models has significantly transformed healthcare. Medical Large Language Models (Med-LLMs) serve as transformative tools that enhance clinical practice through applications in decision support, documentation, and diagnostics. This evaluation examines the performance of leading Med-LLMs, including GPT-4Med, Med-PaLM, MEDITRON, PubMedGPT, and MedAlpaca, across diverse medical datasets. It provides graphical comparisons of their effectiveness in distinct healthcare domains. The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making, documentation, drug discovery, research, patient interaction, and public health. The paper addresses deployment challenges of Medical-LLMs, More >

Adel Saad Assiri^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-21, 2026, DOI:10.32604/cmc.2025.069826 - 10 November 2025

Abstract Customer churn is the rate at which customers discontinue doing business with a company over a given time period. It is an essential measure for businesses to monitor high churn rates, as they often indicate underlying issues with services, products, or customer experience, resulting in considerable income loss. Prediction of customer churn is a crucial task aimed at retaining customers and maintaining revenue growth. Traditional machine learning (ML) models often struggle to capture complex temporal dependencies in client behavior data. To address this, an optimized deep learning (DL) approach using a Regularized Bidirectional Long Short-Term… More >

Ameer Hamza, Robertas Damaševičius^*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-41, 2026, DOI:10.32604/cmc.2025.069721 - 10 November 2025

Abstract This systematic review aims to comprehensively examine and compare deep learning methods for brain tumor segmentation and classification using MRI and other imaging modalities, focusing on recent trends from 2022 to 2025. The primary objective is to evaluate methodological advancements, model performance, dataset usage, and existing challenges in developing clinically robust AI systems. We included peer-reviewed journal articles and high-impact conference papers published between 2022 and 2025, written in English, that proposed or evaluated deep learning methods for brain tumor segmentation and/or classification. Excluded were non-open-access publications, books, and non-English articles. A structured search was… More >

Traian-Radu Ploscă^1,*, Alexandru-Mihai Pescaru², Bianca-Valeria Rus¹, Daniel-Ioan Curiac^1,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-23, 2026, DOI:10.32604/cmc.2025.069707 - 10 November 2025

Abstract Objective expertise evaluation of individuals, as a prerequisite stage for team formation, has been a long-term desideratum in large software development companies. With the rapid advancements in machine learning methods, based on reliable existing data stored in project management tools’ datasets, automating this evaluation process becomes a natural step forward. In this context, our approach focuses on quantifying software developer expertise by using metadata from the task-tracking systems. For this, we mathematically formalize two categories of expertise: technology-specific expertise, which denotes the skills required for a particular technology, and general expertise, which encapsulates overall knowledge More >

Yeasul Kim¹, Chaeeun Won¹, Hwankuk Kim^2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-28, 2026, DOI:10.32604/cmc.2025.069608 - 10 November 2025

Abstract With the increasing emphasis on personal information protection, encryption through security protocols has emerged as a critical requirement in data transmission and reception processes. Nevertheless, IoT ecosystems comprise heterogeneous networks where outdated systems coexist with the latest devices, spanning a range of devices from non-encrypted ones to fully encrypted ones. Given the limited visibility into payloads in this context, this study investigates AI-based attack detection methods that leverage encrypted traffic metadata, eliminating the need for decryption and minimizing system performance degradation—especially in light of these heterogeneous devices. Using the UNSW-NB15 and CICIoT-2023 dataset, encrypted and… More >

Murat Uzam¹, Bernard Berthomieu², Wei Wei^3,*, Yufeng Chen³, Mohammed El-Meligy^4,5, Mohamed Abdel Fattah Sharaf ⁶

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-30, 2026, DOI:10.32604/cmc.2025.069502 - 10 November 2025

Abstract A novel siphon-based divide-and-conquer (SbDaC) policy is presented in this paper for the synthesis of Petri net (PN) based liveness-enforcing supervisors (LES) for flexible manufacturing systems (FMS) prone to deadlocks or livelocks. The proposed method takes an uncontrolled and bounded PN model (UPNM) of the FMS. Firstly, the reduced PNM (RPNM) is obtained from the UPNM by using PN reduction rules to reduce the computation burden. Then, the set of strict minimal siphons (SMSs) of the RPNM is computed. Next, the complementary set of SMSs is computed from the set of SMSs. By the union… More >