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  • Open Access

    ARTICLE

    Predictors of In-Hospital Mortality and Survival Outcomes in a Paediatric Congenital Cardiac Cohort in South Africa—A 12-Year Review

    Prathap Sarma1, Palesa Mogane2,*, Katharina Vanderdonck3, Moses Kebalepile1, Palesa Motshabi Chakane4

    Congenital Heart Disease, Vol.20, No.1, pp. 41-53, 2025, DOI:10.32604/chd.2025.060382 - 18 March 2025

    Abstract Background: Congenital cardiac diseases (CCD) are common congenital birth defects that require high-risk surgery. Outcomes following congenital cardiac surgery in children living in high-income countries (HIC) have been documented, but little is known from the African continent. This study aimed to determine factors associated with perioperative mortality in patients who underwent congenital cardiac surgery at our institution. Methods: This retrospective, cross-sectional study was conducted at Charlotte Maxeke Johannesburg Academic Hospital over 12 years (2006–2017). A multivariable regression analysis was performed for the factors which had a p-value of 0.1 and less in the univariable regression analysis. A… More >

  • Open Access

    ARTICLE

    Failure to Rescue as a Quality Metric in Congenital Heart Surgeries in a High-Complexity Service Provider Institution Located in a Middle-Income Country

    Gustavo Cruz1,*, Santiago Pedroza2, Juan F. Vélez3, Jessica Largo2, Juan F. Tejada4, Jorge H. Mejía-Mantilla5

    Congenital Heart Disease, Vol.19, No.2, pp. 207-218, 2024, DOI:10.32604/chd.2024.044244 - 16 May 2024

    Abstract Background: Failure to rescue has been an effective quality metric in congenital heart surgery. Conversely, morbidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality performance. We aim to measure the complications, mortality, and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar study. Methods: A retrospective observational study was conducted in a high-complexity service provider institution, in Cali, Colombia. All pediatric patients undergoing any congenital heart surgery between… More >

  • Open Access

    ARTICLE

    Impact of Atrial Septal Defect Closure on Mortality in Older Patients

    Sipawath Khamplod1,2, Yodying Kaolawanich1,2, Khemajira Karaketklang3, Nithima Ratanasit1,2,*

    Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631 - 20 March 2024

    Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause… More > Graphic Abstract

    Impact of Atrial Septal Defect Closure on Mortality in Older Patients

  • Open Access

    ARTICLE

    Analysis of Risk Factors for Early Mortality in Surgical Shunt Palliation: Time for a Change?

    François-Xavier Van Vyve1, Karlien Carbonez2, Jelena Hubrechts2, Geoffroy de Beco1, Jean E. Rubay1, Mona Momeni3, Thierry Detaille4, Alain J. Poncelet1,*

    Congenital Heart Disease, Vol.18, No.5, pp. 539-550, 2023, DOI:10.32604/chd.2023.042344 - 10 November 2023

    Abstract Objectives: Over the last decade, neonatal repair has been advocated for many congenital heart diseases. However, specific subgroups of complex congenital heart disease still require temporary palliation for which both surgical and endovascular techniques are currently available. We reviewed our institutional experience with shunt palliation with an emphasis on risk factors for early mortality. Methods: This is a single-center retrospective study on 175 patients undergoing surgery for central shunt or modified Blalock-Taussig shunt. All data were extracted from a prospectively collected computerized database. We identified risk factors for early mortality by uni- and multi-variable analysis.… More >

  • Open Access

    ARTICLE

    Mortality Rates of Ventricular Septal Defect for Children in Kazakhstan: Spatio-Temporal Epidemiological Appraisal

    Akkerbez Adilbekova1,3,*, Shukhrat Marassulov1, Bakhytzhan Nurkeev1, Saken Kozhakhmetov2, Aikorkem Badambekova3

    Congenital Heart Disease, Vol.18, No.4, pp. 447-459, 2023, DOI:10.32604/chd.2023.028742 - 15 September 2023

    Abstract Objective: The aim is to study the trends in ventricular septal defect (VSD) mortality in children in Kazakhstan. Methods: The retrospective study was done for the period 2011–2020. Descriptive and analytical methods of epidemiology were applied. The universally acknowledged methodology used in sanitary statistics is used to calculate the extensive, crude, and age-specific mortality rates. Results: Kazakhstan is thought to be seeing an increase in mortality from VSDs in children. As a result, this study for the years 2011 to 2020 was conducted to retrospectively assess data from the central registration of the Bureau of National… More > Graphic Abstract

    Mortality Rates of Ventricular Septal Defect for Children in Kazakhstan: Spatio-Temporal Epidemiological Appraisal

  • Open Access

    ARTICLE

    Preoperative Fasting of More Than 14 Hours Increases the Risk of Time-to-Death after Cardiothoracic Surgery in Children: A Retrospective Cohort Study

    Laortip Rattanapittayaporn, Maliwan Oofuvong*, Jutarat Tanasansuttiporn, Thavat Chanchayanon

    Congenital Heart Disease, Vol.18, No.1, pp. 23-39, 2023, DOI:10.32604/chd.2023.026026 - 09 January 2023

    Abstract Background: Prolonged preoperative fasting can cause hypoglycemia, hyperglycemia, and intravascular volume depletion in children. We aimed to examine whether prolonged preoperative fasting is associated with in-hospital mortality and other morbidities in pediatric cardiothoracic surgery. Methods: This retrospective cohort study included children aged 0–3 years who underwent cardiac surgery between July 2014 and October 2020. The patient demographic data, surgery-related and anesthesia-related factors, and postoperative outcomes, including hypoglycemia, hyperglycemia, sepsis, length of intensive care unit stay, and in-hospital mortality, were recorded. The main exposure and outcome variables were prolonged fasting and time-to-death after surgery, respectively. The associations between… More > Graphic Abstract

    Preoperative Fasting of More Than 14 Hours Increases the Risk of Time-to-Death after Cardiothoracic Surgery in Children: A Retrospective Cohort Study

  • Open Access

    ARTICLE

    Explainable AI Enabled Infant Mortality Prediction Based on Neonatal Sepsis

    Priti Shaw1, Kaustubh Pachpor2, Suresh Sankaranarayanan3,*

    Computer Systems Science and Engineering, Vol.44, No.1, pp. 311-325, 2023, DOI:10.32604/csse.2023.025281 - 01 June 2022

    Abstract Neonatal sepsis is the third most common cause of neonatal mortality and a serious public health problem, especially in developing countries. There have been researches on human sepsis, vaccine response, and immunity. Also, machine learning methodologies were used for predicting infant mortality based on certain features like age, birth weight, gestational weeks, and Appearance, Pulse, Grimace, Activity and Respiration (APGAR) score. Sepsis, which is considered the most determining condition towards infant mortality, has never been considered for mortality prediction. So, we have deployed a deep neural model which is the state of art and performed More >

  • Open Access

    ARTICLE

    Operative duration and short term morbidity and mortality following radical cystectomy with urinary diversion

    Seth L. Teplitsky1, Patrick J. Hensley1, Amber Bettis2, Andrew James1, Andrew M. Harris1,3

    Canadian Journal of Urology, Vol.29, No.2, pp. 11087-11097, 2022

    Abstract Introduction: To elucidate the association between operative duration (OD) and postoperative complications, which has been poorly studied in radical cystectomy. We hypothesize an increase in morbidity in radical cystectomy cases which have a longer OD.
    Materials and methods: Data from the National Surgical Quality Improvement Program (NSQIP) between the years 2012 and 2018 were reviewed for radical cystectomy with ileal conduit urinary diversion or continent diversion. Total operative time was divided into deciles and stratified comparisons were made using univariable and multivariable analysis.
    Results: A total of 11,128 patients were examined. OD by minutes was stratified into the… More >

  • Open Access

    REVIEW

    Epidemiology of Breast Cancer

    Chao Shang, Dongkui Xu*

    Oncologie, Vol.24, No.4, pp. 649-663, 2022, DOI:10.32604/oncologie.2022.027640 - 31 December 2022

    Abstract All over the world, the most common malignancy in women is breast cancer. Breast cancer is also a significant factor of death in women. In 2020, approximately 2.3 million cases of breast cancer were newly diagnosed in women globally, and approximately 685,000 people died. Breast cancer incidence varies by region around the world, but it is all increasing. According to the current morbidity and mortality trend of breast cancer, it is estimated that by 2030, the number of incidence and deaths of breast cancer will reach 2.64 million and 1.7 million, respectively. The age-standardized incidence… More >

  • Open Access

    ARTICLE

    Mortality and Long-Term Outcome of Neonates with Congenital Heart Disease and Acute Perinatal Stroke: A Population-Based Case-Control Study

    Eszter Vojcek1,2,*, V. Anna Gyarmathy3,4, Rozsa Graf5, Anna M. Laszlo6, Laszlo Ablonczy7, Zsolt Prodan7, Istvan Seri1,8

    Congenital Heart Disease, Vol.17, No.4, pp. 447-461, 2022, DOI:10.32604/chd.2022.022274 - 04 July 2022

    Abstract Objective: Neonates with congenital heart disease (CHD) and perinatal stroke have high mortality and survivors are at risk for poor long-term neurodevelopmental outcome. The aim of this study was to assess the risk factors and outcome of neonates with both CHD and MRI-confirmed perinatal stroke (Study Group) and compare those to the risk factors and outcome of infants matched for CHD without stroke (Control-1) and of infants matched for MRI-confirmed stroke without CHD (Control-2). Methods: We conducted a population-based case-control study enrolling 28 term neonates with CHD and MRI-confirmed acute perinatal stroke born between 2007–2017 in… More > Graphic Abstract

    Mortality and Long-Term Outcome of Neonates with Congenital Heart Disease and Acute Perinatal Stroke: A Population-Based Case-Control Study

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