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  • Open Access


    Measurement of Myopia and Normal Human Choroidal Thickness Using Spectral Domain Optical Coherence Tomography

    Jia Qin1,2,3,4,5, Lin An1,2,3,4,5,*

    Molecular & Cellular Biomechanics, Vol.19, No.3, pp. 151-157, 2022, DOI:10.32604/mcb.2022.018578

    Abstract Myopia is a common ophthalmic deficiency. The structure and function of choroid layer is assumed to be associated with myopia. In this study, a laboratory developed spectral domain optical coherence tomography scanning system is used to image human eyes. The axial resolution of the system is about 7 μm, and the acquisition rate is 100 kHz. Firstly, a cross-sectional image was acquired by averaging 100 images from imaging posterior segment of each eye. The choroid thickness was measured by 11 discrete points. The average thickness of normal human eyes was (0.296 ± 0.126) mm, whereas the average choroid thickness of… More >

  • Open Access


    Biomechanical Characterization of Mouse Sclera in Myopia

    C. Ross Ethier1,*, Dillon M. Brown1, Erica Landis2, Machelle T. Pardue1,2,3

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 61-63, 2019, DOI:10.32604/mcb.2019.07377

    Abstract Myopia, or near-sightedness, is a common ocular condition in which the eye elongates excessively. Development of myopia is associated with, and thought to be facilitated by, changes in the biomechanical properties of the sclera (the white part of the eye). We characterized scleral biomechanics in a mouse model of myopia using unconfirmed compression testing and biphasic theory to extract scleral permeability, in- plane scleral tensile modulus, and through-plane scleral compressive modulus. We find that myopia reduces in-plane tensile modulus and permeability, consistent with scleral tissue remodeling. Such biomechanical outcome measures may offer advantages over more traditional assessments of myopia-associated changes… More >

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