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  • Open Access


    Effect of CSH Crystal Nucleus on Steam-Free Cured Fly Ash Precast Concrete Components

    Ruyi Luo, Yanyan Hu*, Tingshu He*, Xiaodong Ma, Yongdong Xu

    Journal of Renewable Materials, Vol.11, No.9, pp. 3485-3500, 2023, DOI:10.32604/jrm.2023.027592

    Abstract The measures of steam curing and early-strengthening agents to promote the precast components to reach the target strength quickly can bring different degrees of damage to the concrete. Based on this, the new nanomaterial CSH-the hydration product of cement effectively solves these measures’ disadvantages, such as excessive energy consumption, thermal stress damage, and the introduction of external ions. In this paper, the effect of CSH on the early strength of precast fly ash concrete components was investigated in terms of setting time, workability, and mechanical properties and analyzed at the microscopic level using hydration temperature, XRD, and SEM. The results… More >

  • Open Access


    Es-SOX8 regulates the morphological changes of the sperm nucleus of Eriocheir sinensis by activating Es-BMP2 transcription


    BIOCELL, Vol.46, No.11, pp. 2399-2413, 2022, DOI:10.32604/biocell.2022.022015

    Abstract The SRY-related high mobility group (HMG) box (SOX) transcription factors participate in many physiological processes of animal growth, development, and reproduction and are related to spermatogenesis in many species. However, the relationship between SOX and spermatogenesis in Eriocheir sinensis is rarely reported. Here, we studied the role of Es-SOX8 in the spermatogenesis of E. sinensis and its possible regulation mechanism. Immunofluorescence results demonstrated Es-SOX8 signal in both cytoplasm and nucleus of spermatogonia, spermatocytes as well as spermatids, but not in mature spermatozoa. Hematoxylin and eosin staining showed a significant increase in the number of spermatozoa with abnormal nuclear morphology   … More >

  • Open Access


    Possible mechanisms of bidirectional nuclear transport during neuronal migration


    BIOCELL, Vol.46, No.11, pp. 2357-2361, 2022, DOI:10.32604/biocell.2022.021050

    Abstract Neuronal migration is a fundamental process of mammalian brain development. In migrating neurons, the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks. Current evidence has shown that Nesprin-2 binds to both the minus-end-directed motor dynein as well as the plus-end-directed motor kinesin. However, translocation of neuronal nucleus has long been thought to be primarily driven by dynein motors. Intriguing questions could be raised about the role of kinesin in nuclear transport and how the activities of opposing motors are coordinated through interactions with Nesprin. Combining evidence from recent studies,… More >

  • Open Access


    Automatic Leukaemia Segmentation Approach for Blood Cancer Classification Using Microscopic Images

    Anuj Sharma1, Deepak Prashar2, Arfat Ahmad Khan3, Faizan Ahmed Khan4, Settawit Poochaya3,*

    CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 3629-3648, 2022, DOI:10.32604/cmc.2022.030879

    Abstract Leukaemia is a type of blood cancer that is caused by undeveloped White Blood Cells (WBC), and it is also called a blast blood cell. In the marrow of human bones, leukaemia is developed and is responsible for blood cell generation with leukocytes and WBC, and if any cell gets blasted, then it may become a cause of death. Therefore, the diagnosis of leukaemia in its early stages helps greatly in the treatment along with saving human lives. Subsequently, in terms of detection, image segmentation techniques play a vital role, and they turn out to be the important image processing… More >

  • Open Access


    The role of transcriptional factor brachyury in the development and repair of nucleus pulposus


    BIOCELL, Vol.46, No.6, pp. 1363-1364, 2022, DOI:10.32604/biocell.2022.018360

    Abstract Transcription factor Brachyury, a protein containing 435 amino acids, has been widely investigated and reported in notochord differentiation and nucleus pulposus development. The crucial functions and underlying mechanisms by Brachyury are discussed in this paper, which suggests Brachyury can be developed into a potential novel target for the therapy of intervertebral disc degeneration. More >

  • Open Access


    Nucleus Detection on Pap Smear Images for Cervical Cancer Diagnosis: A Review Analysis

    Afiqah Halim1, Wan Azani Mustafa1,2,*, Wan Khairunizam Wan Ahmad1, Hasliza A. Rahim2, Hamzah Sakeran3

    Oncologie, Vol.23, No.1, pp. 73-88, 2021, DOI:10.32604/Oncologie.2021.015154

    Abstract Cervical cancer is a cell disease in the cervix that develops out of control in the female body. The cervix links the vagina (birth canal) with the upper section of the uterus, which can only be found in the female body. This is the second leading cause of death among women around the world. However, cervical cancer is currently one of the most preventable cancers if early detection is identified. The effect of unidentified cancer may increase the risk of death when the cell disease spreads to other parts of the female anatomy (metastasize). The Papanicolaou test is a cervical… More >

  • Open Access


    Microparticle Effect of Carbon Dioxide Hydrate Crystal Nucleus in Reaction Kettle

    Yujie Bai1,*, Youquan Huang3, Guangsheng Cao1, Xiaohan Nan1, Qingchao Cheng1, Lei Wang2, Tong Du4

    Journal of Renewable Materials, Vol.9, No.4, pp. 651-669, 2021, DOI:10.32604/jrm.2021.014479

    Abstract This study analyzed the partial effect of carbon dioxide hydrate in reaction kettle experiments. The particle and bubble characteristics of the crystal nucleus during carbon dioxide hydrate decomposition were observed under the microscope. The results showed that in the temperature range of 0.5°C–3.5°C, the pressure range of 3 MPa– 5.5 MPa, phase characteristics in the reaction kettle changed in a complex fashion during carbon dioxide hydrate formation. During hydrate decomposition, numerous carbon dioxide bubbles were produced, mainly by precipitation at high temperatures or in the hydrate cage structure. The hydrate crystal nucleus initially exhibited fluidity in the reaction. However, as… More >

  • Open Access


    Changes in neuropeptides related to food intake in the rat arcuate nucleus after chronic immobilization stress and the effect of comfortable music exposure


    BIOCELL, Vol.44, No.3, pp. 421-429, 2020, DOI:10.32604/biocell.2020.010257

    Abstract Stress is an inevitable interference factor that seriously affects health. Listening to music is an economical, noninvasive, and highly accepted tool for easing stress. However, physiological studies investigating the ability of music to reduce stress in daily life are limited. We established rat models of chronic immobilization stress (CIS) to observe changes in the hypothalamic arcuate nucleus (ARC) neurons involved in the regulation of food intake and the effect of comfortable classical music exposure. Twenty-one days of stress resulted in decreased food intake and delayed body weight gain; up-regulation of leptin receptor (Ob-R), cocaine- and amphetamine-regulated transcript (CART), proopiomelanocortin (POMC),… More >

  • Open Access


    LOX Alleviates Rat Intervertebral Disc Degeneration Through ECM Improvement and Anti-Apoptotic Protection in Nucleus Pulposus Cells

    Runze Zhao1, Tingting Xia1, Mengyue Wang1, Fan Feng1, Wanqian Liu1,*, Li Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 77-77, 2019, DOI:10.32604/mcb.2019.07155

    Abstract This study was focus on the exploring the therapeutic function of lysyl oxidase (LOX) in rat nucleus pulposus (NP) cells in intervertebral disc degeneration (IVDD). To do this, a Sprague-Dawley (SD) rat caudal spine degeneration model was established by puncturing the Co5-6 disc. NP cells apoptosis and extracellular matrix (ECM) degeneration in IVDD were evaluated by real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR), Hematoxylin-Eosin (H&E) and immunofluorescence. Then, the therapeutic effect of LOX on IVDD was evaluated by histological staining. In vitro, the regulator effect of LOX on degenerate rat NP cell was explored. ECM relate proteins and cytokines were… More >

  • Open Access


    Structure - Function Relationships in the Stem Cell's Mechanical World B: Emergent Anisotropy of the Cytoskeleton Correlates to Volume and Shape Changing Stress Exposure

    Hana Chang*, Melissa L. Knothe Tate∗,†,‡

    Molecular & Cellular Biomechanics, Vol.8, No.4, pp. 297-318, 2011, DOI:10.3970/mcb.2011.008.297

    Abstract In the preceding study (Part A), we showed that prescribed seeding conditions as well as seeding density can be used to subject multipotent stem cells (MSCs) to volume changing stresses and that changes in volume of the cell are associated with changes in shape, but not volume, of the cell nucleus. In the current study, we aim to control the mechanical milieu of live cells using these prescribed seeding conditions concomitant to delivery of shape changing stresses via fluid flow, while observing adaptation of the cytoskeleton, a major cellular transducer that modulates cell shape, stiffness and remodeling. We hypothesize that… More >

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