Machiraju Jayalakshmi^{1, *}, S. Nagaraja Rao²

CMC-Computers, Materials & Continua, Vol.65, No.2, pp. 1081-1096, 2020, DOI:10.32604/cmc.2020.011710

Abstract In recent years, the development in the field of computer-aided diagnosis (CAD) has increased rapidly. Many traditional machine learning algorithms have been proposed for identifying the pathological brain using magnetic resonance images. The existing algorithms have drawbacks with respect to their accuracy, efficiency, and limited learning processes. To address these issues, we propose a pathological brain tumour detection method that utilizes the Weiner filter to improve the image contrast, 2D- discrete wavelet transformation (2D-DWT) to extract the features, probabilistic principal component analysis (PPCA) and linear discriminant analysis (LDA) to normalize and reduce the features, and More >

Yan Cai^1,2,3, Jie Wu⁴, Zhiyong Li^1,2

Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 231-248, 2015, DOI:10.3970/mcb.2015.012.231

Abstract We propose a coupled mathematical model for the detailed quantitative analyses of initial microtumour and micrometastases formation by including cancer cell migration, host vessel cooption and changes in microenvironment. Migrating cells are included as a new phenotype to describe the migration behaviour of malignant tumour cells. Migration probability of a migrating cell is assumed to be influenced by local chemical microenvironment. Pre-existing vessel cooption and remodelling are introduced according to the local haemodynamical microenvironment, such as interstitial pressure and vessel wall permeability. After the tumour cells and tumour vessels distribution are updated, the chemical substances… More >

Jie Wu^∗,†, Quan Long^‡, Shixiong Xu^*, Anwar R. Padhani^§, Yuping Jiang^¶

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 217-228, 2008, DOI:10.3970/mcb.2008.005.217

Abstract In this paper, a 3D mathematical model of tumour angiogenesis is developed, to generate a functional tumour vasculature for blood microcirculation. The model follows that of Anderson and Chaplain (1998) ^[1] with three exceptions: (a) extending the model from 2D to 3D, one arteriole and one venule is induced as two parent vessels to form an intact circulation network for blood flow; (b) generating networks able to penetrate into the tumour interior rather than the exterior only; (c) considering branching generations with different diameters, based on which three groups of vessels, such as arterioles, venules and… More >