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  • Open Access


    Biomechanical Characterization of Mouse Sclera in Myopia

    C. Ross Ethier1,*, Dillon M. Brown1, Erica Landis2, Machelle T. Pardue1,2,3

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 61-63, 2019, DOI:10.32604/mcb.2019.07377

    Abstract Myopia, or near-sightedness, is a common ocular condition in which the eye elongates excessively. Development of myopia is associated with, and thought to be facilitated by, changes in the biomechanical properties of the sclera (the white part of the eye). We characterized scleral biomechanics in a mouse model of myopia using unconfirmed compression testing and biphasic theory to extract scleral permeability, in- plane scleral tensile modulus, and through-plane scleral compressive modulus. We find that myopia reduces in-plane tensile modulus and permeability, consistent with scleral tissue remodeling. Such biomechanical outcome measures may offer advantages over more traditional assessments of myopia-associated changes… More >

  • Open Access


    Fixed Electrical Charges and Mobile Ions Affect the Measurable Mechano-Electrochemical Properties of Charged-Hydrated Biological Tissues: The Articular Cartilage Paradigm

    Leo Q. Wan1,1, Chester Miller1,1, X. Edward Guo2,2, Van C. Mow1,1,3,3

    Molecular & Cellular Biomechanics, Vol.1, No.1, pp. 81-100, 2004, DOI:10.3970/mcb.2004.001.081

    Abstract The triphasic constitutive law [Lai, Hou and Mow (1991)] has been shown in some special 1D cases to successfully model the deformational and transport behaviors of charged-hydrated, porous-permeable, soft biological tissues, as typified by articular cartilage. Due to nonlinearities and other mathematical complexities of these equations, few problems for the deformation of such materials have ever been solved analytically. Using a perturbation procedure, we have linearized the triphasic equations with respect to a small imposed axial compressive strain, and obtained an equilibrium solution, as well as a short-time boundary layer solution for the mechano- electrochemical (MEC) fields for such a… More >

  • Open Access


    The Effect of Matrix Tension-Compression Nonlinearity and Fixed Negative Charges on Chondrocyte Responses in Cartilage

    Morakot Likhitpanichkul1, X. Edward Guo2, Van C. Mow1,3

    Molecular & Cellular Biomechanics, Vol.2, No.4, pp. 191-204, 2005, DOI:10.3970/mcb.2005.002.191

    Abstract Thorough analyses of the mechano-electrochemical interaction between articular cartilage matrix and the chondrocytes are crucial to understanding of the signal transduction mechanisms that modulate the cell metabolic activities and biosynthesis. Attempts have been made to model the chondrocytes embedded in the collagen-proteoglycan extracellular matrix to determine the distribution of local stress-strain field, fluid pressure and the time-dependent deformation of the cell. To date, these models still have not taken into account a remarkable characteristic of the cartilage extracellular matrix given rise from organization of the collagen fiber architecture, now known as the tension-compression nonlinearity (TCN) of the tissue, as well… More >

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