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  • Open Access

    ARTICLE

    Trends, microbiology, and outcomes of infective endocarditis in children during 2000–2010 in the United States

    Shipra Gupta1, Ankit Sakhuja2, Eric McGrath1, Basim Asmar1

    Congenital Heart Disease, Vol.12, No.2, pp. 196-201, 2017, DOI:10.1111/chd.12425

    Abstract Background: We studied the incidence, trend, underlying conditions, microbiology, and outcomes of infective endocarditis (IE) in children during 11 years using Nationwide Inpatient Sample (NIS) database. This is the largest all-payer inpatient care database in the United States containing data for more than 8 million hospital stays from over 1000 hospitals.
    Methods: NIS data from 2000 to 2010 of primary discharge diagnosis of IE in children aged ≤19 years old were studied. Children with underlying congenital heart defects and acquired heart conditions were identified. Microbiological causative agents were recorded. Linear regression was used to assess trend of… More >

  • Open Access

    ARTICLE

    Ability of noninvasive criteria to predict hemodynamically significant aortic obstruction in adults with coarctation of the aorta

    Marco Astengo1,2*, Caroline Berntsson3*, Åse A. Johnsson3,4, Peter Eriksson1,2, Mikael Dellborg1,2

    Congenital Heart Disease, Vol.12, No.2, pp. 174-180, 2017, DOI:10.1111/chd.12424

    Abstract Objective: Coarctation of the aorta (CoA) is a common condition. Adult patients with newly diagnosed CoA and patients with recurring or residual CoA require evaluation of the severity of aortic obstruction. Cardiac catheterization is considered the gold standard for the evaluation of hemodynamically significant CoA. The European Society of Cardiology (ESC) Guidelines for the management of grown-up congenital heart disease (GUCH) include noninvasive criteria for identifying significant CoA. Our aim was to investigate the ability of the Class I and Class IIa ESC recommendations to identify significant CoA at cardiac catheterization.
    Design: Sixty-six adult patients with native… More >

  • Open Access

    ARTICLE

    Effect of solute temperature in the measurement of cardiac output in children using the thermodilution technique

    Shyam Sathanandam1, Pooja Kashyap1, David Zurakowski2, Lindsey Bird1, Vera McGhee3, Jeffrey Towbin1, Benjamin Rush Waller III1

    Congenital Heart Disease, Vol.12, No.2, pp. 181-187, 2017, DOI:10.1111/chd.12423

    Abstract Objectives: The primary aim of this study was to compare thermodilution (TD) cardiac index (TDCi) measured by injecting cold saline (C-TDCi) to saline at room temperature (R-TDCi). The secondary aim was to assess the change in body temperature with cold saline injections in children.
    Design: This is a prospective, case control study.
    Setting: Cardiac catheterization lab at Le Bonheur Children’s Hospital, Memphis, Tennessee.
    Patients: Eighty-six children ≤18 years of age that underwent cardiac catheterization between April 2013 and April 2015, excluding patients with admixing lesions, on inotropic support and with ejection fraction < 30%.
    Interventions: A TD catheter in the… More >

  • Open Access

    ARTICLE

    Serial cardiac MRIs in adult Fontan patients detect progressive hepatic enlargement and congestion

    Matthew J. Lewis1, Elizabeth Hecht2, Jonathan Ginns1, Joshua Benton2, Martin Prince2, Marlon S. Rosenbaum1

    Congenital Heart Disease, Vol.12, No.2, pp. 153-158, 2017, DOI:10.1111/chd.12422

    Abstract Background: The progression of hepatic disease in adult Fontan patients is not well understood. They reviewed the experience with serial cardiac MRIs (CMR) in adult Fontan patients to determine if hepatic anatomic markers of prolonged Fontan exposure were present and if clinical predictors of progressive hepatic congestion could be identified.
    Methods and Results: A retrospective cohort study of all adult Fontan patients who had undergone at least two CMRs was performed. Hepatic dimensions, inferior vena cava (IVC) size, right hepatic vein (RHV) size and spleen diameter were determined from images acquired at the time of clinically guided… More >

  • Open Access

    EDITORIAL

    Guest Editorials for the Coming Year

    Douglas S. Moodie

    Congenital Heart Disease, Vol.12, No.1, pp. 5-5, 2017, DOI:10.1111/chd.12444

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Hydroxymethylfurfural Hardening of Pine Tannin Wood Adhesives

    F.-J. Santiago-Medina1, A. Pizzi1,2,*, S. Abdalla2

    Journal of Renewable Materials, Vol.5, No.5, pp. 435-447, 2017, DOI:10.7569/JRM.2017.634166

    Abstract An adhesive based on the reaction of a very fast reacting procyanidin-type condensed tannin, namely purified pine bark tannin, with a biosourced nontoxic and nonvolatile aldehyde derived from the pulp and paper industry, namely hydroxymethylfurfural (HMF), was shown to almost satisfy the relevant standards for bonding wood particleboard. The conditions of pH used are determinant for the result. The oligomers obtained by the reaction and their distribution have been determined by matrix-assisted laser ionization desorption time-of-flight (MALDI-TOF) mass spectrometry. Of the two reactive groups of hydroxymethylfurfural capable of reacting, the furanic aldehyde one and the More >

  • Open Access

    ARTICLE

    Use of 3D models of congenital heart disease as an education tool for cardiac nurses

    Giovanni Biglino1,2, Claudio Capelli2,3, Despina Koniordou3, Di Robertshaw2, Lindsay-Kay Leaver2, Silvia Schievano2,3, Andrew M. Taylor2,3, Jo Wray2

    Congenital Heart Disease, Vol.12, No.1, pp. 113-118, 2017

    Abstract Background: Nurse education and training are key to providing congenital heart disease (CHD) patients with consistent high standards of care as well as enabling career progression. One approach for improving educational experience is the use of 3D patient-specific models.
    Objectives: To gather pilot data to assess the feasibility of using 3D models of CHD during a training course for cardiac nurses; to evaluate the potential of 3D models in this context, from the nurses’ perspective; and to identify possible improvements to optimise their use for teaching.
    Design: A cross-sectional survey.
    Setting: A national training week for cardiac nurses.
    Participants: One… More >

  • Open Access

    ARTICLE

    A population-based analysis of mortality in patients with Turner syndrome and hypoplastic left heart syndrome using the Texas Birth Defects Registry

    Diego A. Lara1, Mary K. Ethen2, Mark A. Canfield2, Wendy N. Nembhard3, Shaine A. Morris1

    Congenital Heart Disease, Vol.12, No.1, pp. 105-112, 2017

    Abstract Background: Hypoplastic left heart syndrome (HLHS) is strongly associated with Turner syndrome (TS); outcome data when these conditions coexist is sparse. We aimed to investigate long-term survival and causes of death in this population.
    Methods: The Texas Birth Defects Registry was queried for all live born infants with HLHS during 1999–2007. We used Kaplan–Meier and Cox regression analyses to compare survival among patients with HLHS with TS (HLHS/TS+) to patients who had HLHS without genetic disorders or extracardiac birth defects (HLHS/TS–).
    Results: Of the 542 patients with HLHS, 11 had TS (2.0%), 71 had other extracardiac birth defects… More >

  • Open Access

    ARTICLE

    Electrocardiographic early repolarization characteristics and clinical presentations in the young: a benign finding or worrisome marker for arrhythmias

    Raya Safa, Ronald Thomas, Peter P. Karpawich

    Congenital Heart Disease, Vol.12, No.1, pp. 99-104, 2017

    Abstract Background: The early ECG repolarization QRS pattern (ERp), with J-point elevation of 0.1 mV in two contiguous inferior and/or lateral leads, can be associated with ventricular arrhythmias among adults. The significance of an ERp in the young is unknown.
    Objective: The purpose of this study was to assess the prevalence of ERp among young patients (pts), describe and correlate the characteristics with clinical presentations and any arrhythmias.
    Methods: This was a 1 y retrospective review of ECGs obtained from patients referred specifically for documented arrhythmias, possible arrhythmia-related symptoms or sports clearance. ECGs were analyzed for ERp (J-point, ascending/horizontal… More >

  • Open Access

    ARTICLE

    Neurocognitive and executive functioning in adult survivors of congenital heart disease

    Leda Klouda1, Wayne J. Franklin1, Anita Saraf1,2, Dhaval R. Parekh1, David D. Schwartz3

    Congenital Heart Disease, Vol.12, No.1, pp. 91-98, 2017

    Abstract Objective: Congenital heart disease (CHD) can affect the developing central nervous system, resulting in neurocognitive and behavioral deficits. Preoperative neurological abnormalities as well as sequelae of the open heart operations required to correct structural abnormalities of the heart contribute to these deficits. There are few studies examining the neurocognitive functioning of adults with CHD. This study sought to investigate multiple domains of neurocognitive functioning in adult survivors of CHD who had childhood cardiac surgery with either moderate or severe disease complexity.
    Design: A total of 48 adults (18–49 years of age) who had undergone cardiac surgery for… More >

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