Open Access

ARTICLE

Validation of 1997 Partin Tables’ lymph node invasion predictions in men treated with radical prostatectomy in Montreal Quebec

Pierre I Karakiewicz, Jean-Baptiste Lattouf, Paul Perrotte, Luc Valiquette, François Bénard, Michael McCormack, Catherine Ménard, Thierry Lebeau, Serge Benayoun, Alvaro Ramirez, Simon Ouaknine, Fred Saad

Department of Surgery (Urology), Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada
Address correspondence to Dr. Pierre I. Karakiewicz, Prognostics and Outcomes Unit, CHUM, 1058, rue St-Denis, Montreal, Quebec H2X 3J4 Canada

Canadian Journal of Urology 2005, 12(2), 2588-2592.

Abstract

Objective: The accuracy of 1997 Partin Tables' lymph node invasion (LNI) predictions exhibits important variability in different testing populations. We explored the LNI predictive accuracy in radical prostatectomy (RP) patients from Montreal, Canada. Moreover, we assessed the extent of change in predictive accuracy related to a modification of PSA coding from categorical to continuous.
Methods: We used pretreatment serum PSA, clinical stage, and biopsy Gleason sum from 537 men treated with RP to compare predicted and observed rates of LNI. Accuracy was quantified with receiver-operating characteristics curves.
Results: Accuracy was 0.760 in 369 evaluable patients, when categorically coded pretreatment PSA (0-4, 4.1-10, 10.1-20, 20.1+) was combined with clinical stage and biopsy Gleason sum. A 2.7% accuracy increase was noted when categorically coded PSA was replaced with continuously coded values.
Conclusion: Partin Tables' LNI predictions showed comparable accuracy to a community-based sample from the United States (0.766), and to a recent, multi-institutional sample (0.740). However, accuracy was lower than reported in internal (0.818), and external (0.837) academic, validation cohorts. Accuracy of LNI predictions was appreciably higher, when continuously coded PSA was used.

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