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ARTICLE
Defining high-risk prostate cancer: current status
Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Address correspondence to Dr. Neil Fleshner, Division
Head, Urology, University Health Network, 610 University
Avenue, Toronto, Ontario M5G 2M9 Canada
Canadian Journal of Urology 2005, 12(Suppl.1), 14-17.
Abstract
Defining men at high risk for prostate cancer treatment failure and death continues to evolve. Identifying these men allows for better disease prognostication, patient decision treatment making and facilitates accrual for appropriate clinical trials. Men at traditional high risk for prostate cancer progression and death include men with advanced clinical stage, higher levels of PSA and Gleason pattern 4. Utilizing accepted methods of risk stratification including nomograms can aid in case identification. Softer risk factors such as obesity, race, socioeconomic status, and genetic polymorphisms are increasingly being studied. Ultimately high-throughput genomics will aid in identification of these men.Keywords
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Copyright © 2005 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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