Open Access

ARTICLE

Effectiveness of Maximal Androgen Blockade (MAB): illusion or reality?

Hideyuki Akaza

Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Address correspondence to Dr. H. Akaza, Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan

Canadian Journal of Urology 2005, 12(Suppl.1), 77-80.

Abstract

Two decades have passed since the concept of Maximal Androgen Blockade (MAB) was first applied to the clinical treatment of prostate cancer. The theory is that by cutting off the supply of androgen from the adrenal gland, androgen blockade of the prostate could be made more complete. However, to date the clinical benefit of MAB has failed to live up to the theoretically expected effect. Having said that, fundamental research and clinical trials in recent years do indicate that the benefit of MAB is not merely an illusion.

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