Open Access

CASE REPORT

Metastatic urachal cancer responding to FOLFOX chemotherapy

Ben Tran, Joe McKendrick

Department of Medical Oncology, Box Hill Hospital, Victoria, Australia
Address correspondence to Dr. Ben Tran, 3/361 Cotham Rd, Kew, VIC 3101 Australia

Canadian Journal of Urology 2010, 17(2), 5120-5123.

Abstract

Metastatic urachal cancer is a rare disease and subsequently, does not have a defi ned systemic treatment. Although urachal cancer is most commonly adenocarcinoma and histologically similar to colon cancer, treatment selection is usually based upon location (the proximity of the urachus to the bladder) with bladder cancer regimens the most commonly prescribed. We report a case of metastatic urachal cancer where the immunohistochemical profi le’s similarities to colon cancer led to treatment with colon cancer specifi c chemotherapy. Our case is the fi rst to report urachal cancer treated with and responding to modifi ed FOLFOX6. In the age of targeted therapy, where molecular biology drives treatment selection, our case highlights that in rare tumors, when evidence is often lacking, a common sense approach can often prevail.

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