Open Access

ARTICLE

Percutaneous cryoablation for recurrent low grade renal cell carcinoma after failed nephron-sparing surgery

Matthew A. Morgan¹, Nathan R. Roberts², Laura A. Pino¹, Edouard J. Trabulsi^2,3, Daniel B. Brown^1,3, Leonard G. Gomella^2,3, Costas D. Lallas^2,3

1 Division of Interventional Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
2 Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
3 The Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Address correspondence to Dr. Costas Lallas, Department of Urology, Thomas Jefferson University, 1025 Walnut Street, Suite 1112 College Building, Philadelphia, PA 19107 USA

Canadian Journal of Urology 2013, 20(5), 6933-6937.

Abstract

Introduction: Partial nephrectomy has a 3%-4% incidence of local treatment failure. This study is to present a series of percutaneous cryoablation for locally recurrent renal cell carcinoma after partial nephrectomy.
Materials and methods: Five consecutive patients were referred to our quaternary center’s multidisciplinary Small Renal Mass (SRM) Center for assessment after failure of partial nephrectomy. Tumor size and location was noted. CT-guided cryoablation was performed using an argon/helium-based system (Healthtronics, Austin, Texas, USA). Patients were admitted overnight for observation. Patients were followed with serial imaging, laboratory tests and examination at our SRM Center. Tumor size, location, and nephrometry scores were documented for each patient.
Results: Four tumors were endophytic and one was exophytic. The median tumor size was 2.2 cm (1.8 cm–4.0 cm). Nephrometry scores were 8a, 7x, 4p, 6x, 7p, and 6p prior to cryoablation. Median follow-up after cryoablation was 32 months (20–39 months). One patient with a 4.0 cm endophytic tumor developed a second recurrence measuring 2.9 cm 13 months following ablation, which was managed successfully with repeat cryoablation with no evidence of disease after an additional 19 months of follow-up. Two patients developed self-limited hematuria which was conservatively managed. There were no other complications, and all patients remained at their pretreatment performance status.
Conclusions: Percutaneous cryoablation appears to be a safe and effective nephron-sparing modality for control of locally recurrent disease following partial nephrectomy. Most recurrent tumors are endophytic. One patient suffered a second local recurrence, which was managed successfully with repeat cryoablation.

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