Open Access

ARTICLE

An online UPOINT tool for phenotyping patients with chronic prostatitis

Christine N. Tran¹, Jianbo Li², Daniel A. Shoskes¹

1 The Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
2 Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA
Address correspondence to Dr. Daniel A. Shoskes, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk Q10-1, Cleveland OH 44195 USA

Canadian Journal of Urology 2014, 21(2), 7195-7200.

Abstract

Introduction: To evaluate the clinical phenotypes of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) using a web based online tool and to compare these clinical features with patients evaluated in a tertiary referral clinic.
Materials and methods: Data was collected from 720 men who gave complete online responses on a website which determines the UPOINT clinical phenotype in CP/CPPS and measures symptom severity with the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). This was compared to phenotype and symptom severity of 220 patients evaluated in person at a tertiary referral clinic.
Results: The web-based cohort had CPSI scores of 11.1, 4.8, 7.6, and 23.6 for pain, urinary, quality-of-life, and total score, respectively. The percentage of patients positive for each domain was 76%, 74%, 75%, 10%, 46%, and 75% for the urinary, psychosocial, organ specific, infection, neurologic/systemic, and tenderness domains, respectively. There was a positive correlation between CPSI and number of positive UPOINT domains (ρ = 0.25, p < 0.0001). Comparison between web- and clinic-based groups showed that the clinic group had fewer UPOINT positive domains compared to the web-based group (2.9 versus 3.6, p < 0.0001), but had worse quality-of-life (9.0 versus 7.6, p < 0.0001) and CPSI total scores (25.0 versus 23.6, p = 0.0052).
Conclusions: Men using an online tool to clinically phenotype CP/CPPS show similar correlations between UPOINT domains, symptom severity, age and duration. While symptom severity was worse in patients seen in a tertiary referral clinic, the differences were small.

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