Open Access

RESIDENT’S CORNER

Synchronous, but separate, bladder and vaginal rhabdomyosarcoma: a novel genetic case report

Bradley A. Morganstern¹, Samantha Scaccia¹, Wayland Wu¹, Alex K. Williamson², Lane S. Palmer¹

1 DivisionofPediatricUrology,CohenChildren’sMedicalCenterofNY,NorthwellHealth,HofstraNorthwellSchoolofMedicine,LongIsland, New York, USA
2 Department of Pathology – Anatomical, Cohen Children’s Medical Center of NY, Northwell Health, Hofstra Northwell School of Medicine, Long Island, New York, USA
Address correspondence to Dr. Bradley Morganstern, Division of Pediatric Urology, Cohen Children’s Medical Center of New York, Northwell Health, Hofstra Northwell Schoolof Medicine, 1999 Marcus Avenue, M18, Lake Success, NY 11042 USA

Canadian Journal of Urology 2018, 25(3), 9357-9359.

Abstract

Embryonal rhabdomyosarcoma is a rare cancer that often requires multimodality therapy to treat; however, these therapies can cause changes in the biology of the tumor. Several reports have documented pathologic changes but only recently have genetic changes been mapped. We present case of two separate synchronous primary rhabdomyosarcomas in a 17-month-old patient and discuss the pathophysiology and genetic changes that occur with treatment. We hypothesize that a genetic feld defect arising in development of the urogenital sinus caused the tumors, but that treatment modalities may have caused genetic alterations changing clinical behavior of the tumors and responses to treatment.

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