Open Access

RESIDENT’S CORNER

Solitary brain metastasis after recurrent adenocarcinoma of the prostate

Miguel Rodriguez-Homs¹, Brett Wiesen¹, Mona Rizeq², Colin Randau³, Granville L. Lloyd⁴

1 Division of Urology, University of Colorado School of Medicine, Aurora, Colorado, USA
2 Department of Pathology, Veteran’s Administration Medical Center, Aurora, Colorado, USA
3 Department of Radiology, Veteran’s Administration Medical Center, Aurora, Colorado, USA
4 Department of Surgery/Urology, Veteran’s Administration Medical Center, Aurora, Colorado, USA
Address correspondence to Dr. Granville L. Lloyd, Department of Surgery/Urology, Veteran’s Administration Medical Center, 1700 N Wheeling St, Aurora, CO 80045 USA

Canadian Journal of Urology 2021, 28(1), 10565-10567.

Abstract

Prostate cancer is rarely metastatic to visceral organs, and even less commonly to the brain. Recent data suggests brain metastasis from prostatic adenocarcinoma occur in 0.16% of patients, and almost universally in the setting of very high-volume disease. We present a man with an abruptly symptomatic brain lesion that developed at a PSA value of 1.5 ng/mL with no other known metastatic disease and required emergent neurosurgical resection. The patient had been initially treated with radiotherapy for Grade Group 4 prostate cancer in 2005 with a long period of PSA suppression.

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