Open Access

CASE REPORT

Incorrect biochemistry complicates prostate cancer management

Iain McAuley¹, Gary Steinhoff¹, Michael McNeely², Paul Blood³

1 Department of Urology, Capital Health Region, Royal Jubilee Hospital, Victoria, BC, Canada
2 MDS Lab Services, Capital Health Region, Royal Jubilee Hospital, Victoria, BC, Canada
3 Department of Radiation Therapy, Captial Health Region, Royal Jubilee Hospital, Victoria, BC, Canada
Address correspondence to Dr. Iain McAuley, 200-1121 Yates Street, Victoria, BC V8V 3Nl Canada

Canadian Journal of Urology 2002, 9(2), 1496-1497.

Abstract

A man with a prostate specific antigen (PSA) of 6.1 ng/mL, a clinical stage T2b prostate nodule and biopsies that showed Gleason sum 6 adenocarcinoma of the prostate underwent a radical prostatectomy. The final pathology showed organ-confined disease. His postoperative PSA remained elevated at 4.0 ng/mL. The PSA was repeated several times and was in the same range. It was re-evaluated at another lab facility and was unmeasurable ( <0.02 ng/mL). He has an antibody that cross-reacts with an assay reagent causing this false reading. The most likely antibody is one against mouse immunoglobulin G (IgG).

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