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Study of Effect of Boundary Conditions on Patient-Specific Aortic Hemodynamics

Qingzhuo Chi1, Huimin Chen1, Shiqi Yang1, Lizhong Mu1,*, Changjin Ji2, Ying He1, Yong Luan3

1 Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, Dalian University of Technology, Dalian, 116024, China
2 School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China
3 Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China

* Corresponding Author: Lizhong Mu. Email: email

(This article belongs to this Special Issue: Recent Advances in Biomechanics and Biomimetic Mechanics)

Computer Modeling in Engineering & Sciences 2022, 131(1), 31-47.


Cardiovascular computational fluid dynamics (CFD) based on patient-specific modeling is increasingly used to predict changes in hemodynamic parameters before or after surgery/interventional treatment for aortic dissection (AD). This study investigated the effects of flow boundary conditions (BCs) on patient-specific aortic hemodynamics. We compared the changes in hemodynamic parameters in a type A dissection model and normal aortic model under different BCs: inflow from the auxiliary and truncated structures at aortic valve, pressure control and Windkessel model outflow conditions, and steady and unsteady inflow conditions. The auxiliary entrance remarkably enhanced the physiological authenticity of numerical simulations of flow in the ascending aortic cavity. Thus, the auxiliary entrance can well reproduce the injection flow from the aortic valve. In addition, simulations of the aortic model reconstructed with an auxiliary inflow structure and pressure control and the Windkessel model outflow conditions exhibited highly similar flow patterns and wall shear stress distribution in the ascending aorta under steady and unsteady inflow conditions. Therefore, the inflow structure at the valve plays a crucial role in the hemodynamics of the aorta. Under limited time and calculation cost, the steady-state study with an auxiliary inflow valve can reasonably reflect the blood flow state in the ascending aorta and aortic arch. With reasonable BC settings, cardiovascular CFD based on patient-specific AD models can aid physicians in noninvasive and rapid diagnosis.


Cite This Article

Chi, Q., Chen, H., Yang, S., Mu, L., Ji, C. et al. (2022). Study of Effect of Boundary Conditions on Patient-Specific Aortic Hemodynamics. CMES-Computer Modeling in Engineering & Sciences, 131(1), 31–47.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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