Vol.116, No.2, 2018, pp.115-125, doi: 10.31614/cmes.2018.04076
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ARTICLE
Angle of Attack Between Blood Flow and Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy: An In Vivo Multi-patient CT-based FSI Study
  • Long Deng1, Xueying Huang2,3,*, Heng Zuo4, Yuan Zheng2, Chun Yang5, Yunhu Song1, Dalin Tang6
Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
School of Mathematical Sciences, Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computation, Xiamen University, Xiamen, Fujian, China.
Department of Mathematical Sciences, Worcester Polytechnic Institute, MA, USA.
School of Mathematical Sciences, Sichuan Normal University, Chengdu, Sichuan, China.
China Information Technology Designing & Consulting Institute Co., Ltd., Beijing, China.
School of Biological Science & Medical Engineering, Southeast University, Nanjing, China.
* Corresponding Author: Xueying Huang. Email: .
(This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract
The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t wao vs. 56.2±56.o, p=0.306, n=5). Therefore, we propose that the angle of attack might not play an important role in the initiation of SAM.
Keywords
Hypertrophic obstructive cardiomyopathy, systolic anterior motion, mitral valve leaflets, computational model, angle of attack.
Cite This Article
Deng, L., Huang, X., Zuo, H., Zheng, Y., Yang, C. et al. (2018). Angle of Attack Between Blood Flow and Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy: An In Vivo Multi-patient CT-based FSI Study. CMES-Computer Modeling in Engineering & Sciences, 116(2), 115–125.
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