Table of Content

Open Access


In Vivo/Ex Vivo MRI-Based 3D Non-Newtonian FSI Models for Human Atherosclerotic Plaques Compared with Fluid/Wall-Only Models

Chun Yang1, Dalin Tang2, Chun Yuan3, Thomas S. Hatsukami4, Jie Zheng5, Pamela K. Woodard5
Math Dept, Beijing Normal University, Beijing, China
Corresponding author,, Math Dept, WPI, Worcester, MA 01609 USA
Department of Radiology, University of Washington, Seattle, WA 98195 USA
Division of Vascular Surgery, University of Washington, Seattle, WA. 98195 USA
Mallinkcrodt Institute of Radiology, Washington University, St. Louis, MO 63110 USA

Computer Modeling in Engineering & Sciences 2007, 19(3), 233-246.


It has been recognized that fluid-structure interactions (FSI) play an important role in cardiovascular disease initiation and development. However, in vivo MRI multi-component FSI models for human carotid atherosclerotic plaques with bifurcation and quantitative comparisons of FSI models with fluid-only or structure-only models are currently lacking in the literature. A 3D non-Newtonian multi-component FSI model based on in vivo/ex vivo MRI images for human atherosclerotic plaques was introduced to investigate flow and plaque stress/strain behaviors which may be related to plaque progression and rupture. Both artery wall and plaque components were assumed to be hyperelastic, isotropic, incompressible and homogeneous. Blood flow was assumed to be laminar, non-Newtonian, viscous and incompressible. In vivo/ex vivo MRI images were acquired using histologically-validated multi-spectral MRI protocols. The 3D FSI models were solved and results were compared with those from a Newtonian FSI model and wall-only/fluid-only models. A 145% difference in maximum principal stresses (Stress-P1) between the FSI and wall-only models and 40% difference in flow maximum shear stress (MSS) between the FSI and fluid-only models were found at the throat of the plaque using a severe plaque sample (70% severity by diameter). Flow maximum shear stress (MSS) from the rigid wall model is much higher (20-40% in maximum MSS values, 100-150% in stagnation region) than those from FSI models.


Finite element method, artery, blood flow, fluid-structure interaction, atherosclerosis.

Cite This Article

Yang, C., Tang, D., Yuan, C., Hatsukami, T. S., Zheng, J. et al. (2007). In Vivo/Ex Vivo MRI-Based 3D Non-Newtonian FSI Models for Human Atherosclerotic Plaques Compared with Fluid/Wall-Only Models. CMES-Computer Modeling in Engineering & Sciences, 19(3), 233–246.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 909


  • 696


  • 0


Share Link

WeChat scan