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Drug Delivery: From a Contact Lens to the Anterior Chamber

J.A. Ferreira2,3, P. de Oliveira2, P. Silva4, J.N. Murta5
This work was partially supported by Projects:PTDC/MAT/74548/2006, UTAustin/MAT/0066/2008
CMUC, Department of Mathematics, University of Coimbra. 3001-454, Coimbra, Portugal
Email of the corresponding author: ferreira@mat.uc.pt
Department of Physics and Mathematics, ISEC. Rua Pedro Nunes, Quinta da Nora, 3030-199 Coimbra, Portugal
Department of Ophthalmology, Faculty of Medicine, University of Coimbra, Portugal

Computer Modeling in Engineering & Sciences 2011, 71(1), 1-14. https://doi.org/10.3970/cmes.2011.071.001

Abstract

Mathematical models to describe drug concentration profiles of topically administered drug in the anterior chamber aqueous humor have been proposed by several authors. The aim of this paper is to present a mathematical model to predict the drug concentration in the anterior chamber when a therapeutical contact lens with the drug entrapped in nanoparticles is used.

Keywords

Ophthalmic contact lens, nanoparticles, polymeric matrix, cornea, anterior chamber, diffusion.

Cite This Article

Ferreira, J., Oliveira, P. D., Silva, P., Murta, J. (2011). Drug Delivery: From a Contact Lens to the Anterior Chamber. CMES-Computer Modeling in Engineering & Sciences, 71(1), 1–14.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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