Open Access

ARTICLE

Th₁-Th₂ response in hyperprolactinemic mice infected with Salmonella enterica serovar Typhimurium

R. Meli^a, C. Bentivoglio^b, I. Nuzzo^b, G. Mattace Raso^a, E. Galdiero^b, M. Galdiero², R. Di Carlo^a, C. Romano Carratelli^b

a Department of Experimental Pharmacology, University of Naples Federico II
b Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Faculty of Medicine and Surgery, Second University of Naples, Via S. Maria di Costantinopoli, 16, 80138 Naples, Italy

* Corresponding Author: Caterina Romano Carratelli,

European Cytokine Network 2003, 14(3), 186-191.

Abstract

Prolactin (PRL) is a pituitary hormone and a cytokine known to regulate several physiological functions. It plays a role in modulating the immune system of rodents and humans. A hormonal protection against listeria and salmonella infections has been previously ascribed to effects of PRL on immunocompetent cells. Here, the role of PRL in the Th1-Th2 response was evaluated based on the pattern of cytokines release by splenocytes from hyperprolactinemic mice infected with Salmonella enterica serovar Typhimurium.
Hyperprolactinemia by pituitary graft reduced the number of bacteria in spleens of in vivo infected mice. Modulation of Th1 (IFN-γ, IL-12) and Th2 (Il-4, IL-10) cytokine production by splenic cells was found. Our results indicate that PRL can up-regulate IFN-γ and IL-12 secretion in response to salmonella infection, confirming its in vivo immunostimulatory effect and suggesting hormonal participation in the genesis and sustenance of the Th1 response.

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