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Increased serum CNTF level in patients with amyotrophic lateral sclerosis
Department of Neurology, Medical University, Lublin, Poland
European Cytokine Network 2003, 14(3), 192-194.
Abstract
The role of ciliary neurotrophic factor (CNTF) in the etiopathogenesis of amyotrophic lateral sclerosis (ALS) is still not clear. The aim of this study was to measure serum CNTF level in patients with ALS. The study involved 36 ALS patients and 43 control group subjects. CNTF was measured by the enzyme‐‐linked immunosorbent assay. Results showed that the serum CNTF level in whole group of ALS patients was significantly higher from those in the total control group subjects. CNTF level was not dependent on the clinical state of the ALS patients, type of ALS onset, or duration of the disease. Results indicate that CNTF may be a reactive component resulting from the disease, but it cannot be a marker of ALS activity. It is possible that the increase in serum CNTF level is the result of the muscle denervation seen in this disease.Keywords
amyotrophic lateral sclerosis, ciliary neurotrophic factor, denervation, muscle, serum
Cite This Article
APA Style
Iłżecka, J. (2003). Increased serum CNTF level in patients with amyotrophic lateral sclerosis. European Cytokine Network, 14(3), 192–194.
Vancouver Style
Iłżecka J. Increased serum CNTF level in patients with amyotrophic lateral sclerosis. Eur Cytokine Network. 2003;14(3):192–194.
IEEE Style
J. Iłżecka, “Increased serum CNTF level in patients with amyotrophic lateral sclerosis,” Eur. Cytokine Network, vol. 14, no. 3, pp. 192–194, 2003.
Copyright © 2003 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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