Open Access

ARTICLE

Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation

Davy W. Matondo Maya^1,2, Ludovic Mewono^1,2, Anne-Marie Nkoma¹, Saadou Issifou¹, Elie Mavoungou¹

1 Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon
2 Department of Parasitology, Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany

* Corresponding Author: E. Mavoungou,

European Cytokine Network 2008, 19(3), 123-130. https://doi.org/10.1684/ecn.2008.0129

Accepted 01 July 2008;

Abstract

We investigated associations between markers of damage of vascular endothelial cells (MDVECs) and plasma cytokine levels, hemoglobin level and temperature in individuals with acute uncomplicated malaria, as well as healthy controls, using enzyme linked immunosorbent assay (ELISA) for the presence of soluble endothelial cell adhesion molecule-1 (sE-selectin), circulating granule membrane protein-140 (sP-selectin), circulating thrombomodulin (TM), circulating von Willebrand factor (VWf), interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). Significant differences were observed between malaria patients and the healthy people in term of levels of both sE-selectin and TM. The serum levels of sP-selectin and VWf were comparable between the two groups. The levels of both sE-Selectin and TM correlated positively with temperature, levels of IFN-γ and levels of TNF-α; and negatively with hemoglobin levels. Trends of positive correlations were observed between level of sP-selectin or VWf and temperature. Furthermore, sE-selectin levels correlated with vomiting. These data suggest that sE-selectin and TM might be useful markers of endothelium activation in in vivo studies. Moreover, our results highlight the use of both sE-selctin and TM as markers of anemia.

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Keywords

adhesion molecules, Plasmodium falciparum, TNF-a, IFN-c, Gabon

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Cite This Article

APA Style

Maya, D.W.M., Mewono, L., Nkoma, A., Issifou, S., Mavoungou, E. (2008). Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation. European Cytokine Network, 19(3), 123–130. https://doi.org/10.1684/ecn.2008.0129

Vancouver Style

Maya DWM, Mewono L, Nkoma A, Issifou S, Mavoungou E. Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation. Eur Cytokine Network. 2008;19(3):123–130. https://doi.org/10.1684/ecn.2008.0129

IEEE Style

D.W.M. Maya, L. Mewono, A. Nkoma, S. Issifou, and E. Mavoungou, “Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation,” Eur. Cytokine Network, vol. 19, no. 3, pp. 123–130, 2008. https://doi.org/10.1684/ecn.2008.0129

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