Open Access

REVIEW

IL-23R Arg381Gln polymorphism in Chilean patients with inflammatory bowel disease

Mauricio Venegas¹, Caroll J. Beltrán², Luis Álvarez¹, Ariel Castro³, Tamara Torres⁴, Andrea D. Leal⁵, Francisca M. Lahsen⁵, Marcela A. Hermoso², Rodrigo Quera^1,6

1 Department of Medicine, Gastroenterology, Hospital Clínico, Universidad de Chile
2 Immunology Disciplinary Program, Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile
3 Department of Epidemiology
4 Department of Investigation, Hospital Clínico, Universidad de Chile
5 Student of Medicine, Faculty of Medicine, Universidad de Chile
6 Section of Gastroenterology, Clínica Las Condes, Santiago, Chile

* Corresponding Author: R. Quera,

European Cytokine Network 2008, 19(4), 190-195. https://doi.org/10.1684/ecn.2008.0135

Accepted 24 September 2008;

Abstract

Crohn’s disease (CD) and ulcerative colitis (UC) are multifactorial diseases with a genetic back-ground. Recent results have shown that a non-synonymous, single nucleotide polymorphism (rs11209026, c.1142G>A, p.Arg381Gln) located in the IL-23R gene is associated with inflammatory bowel disease (IBD). The prevalence of IBD is rapidly rising in Chile and there is no information about the frequency of this polymor-phism in the Chilean population. Aim. To assess the distribution of DNA variants in the IL-23R gene in Chilean patients with IBD. Methods. We studied 100 IBD patients (38 CD and 62 UC) and 59 healthy controls. IL-23R Arg381Gln (G1142A) was genotyped by the polymerase chain reaction and restriction fragment length polymor-phism assay. Clinical and demographic features were characterized. Results. The IL-23R genetic variant did not have an association with IBD in Chilean patients. This polymorphism was present in 5.2% of the control group and 5% of IBD patients (7.9% for CD and 3.2% for UC) (p > 0.05). Conclusions. These results suggest that the IL-23R Arg381Gln seems not to be involved in the genetic predisposition to IBD in a Chilean population, and confirms that there are ethnic differences in the genetic background of IBD. Replication studies by independent groups are necessary to elucidate the contribution of susceptibility genes to IBD in different ethnic populations.

---

Keywords

---