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Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
1 University of Inonu, Faculty of Medicine, Dept. of Internal Medicine, 44280, Malatya, Turkey
2 University of Inonu, Faculty of Pharmacy, Dept. of Pharmaceutical Toxicology, 44280, Malatya, Turkey
3 University of Inonu, Faculty Medicine, Dept. of Histology, 44280, Malatya, Turkey
4 University of Inonu, Faculty of Medicine, Dept. of Anatomy, 44280, Malatya, Turkey
European Cytokine Network 2013, 24(2), 91-96. https://doi.org/10.1684/ecn.2013.0337
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The objective of the current study was to investigate the protective effects of hesperidin against oxidative stress, altered cytokines levels and histological changes in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were divided randomly into four equal groups (Control, TCDD, hesperidin and TCDD+hesperidin). TCDD and hesperidin were given by gavage, dissolved in corn oil at doses of 2 μ/kg/week and 50 mg/kg/day respectively. The blood and tissue samples were taken from all rats on the 60th day, to be analyzed for the determination of oxidative stress, histological changes and cytokine levels. The results indicated that hesperidin prevented oxidative damage caused by TCDD via decrease lipid peroxidation and increased antioxidant defense systems. It also reversed the histological damage induced by TCDD. Although, TCDD led to a significant increase in TNF-α and IL-1 β levels, hesperidin treatment was able to normalize these values in rats. In conclusion, it was shown that TCDD caused adverse effects as regards cytokine levels, histological alterations and oxidative stress in rats. However, hesperidin treatment mitigated these toxic effects. These results suggest that hesperidin could play a protective role against TCDD toxicity.Keywords
TCDD, hesperidin, cytokine, oxidative stress, histological alterations
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APA Style
Bentli, R., Ciftci, O., Cetin, A., Unlu, M., Basak, N. et al. (2013). Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). European Cytokine Network, 24(2), 91–96. https://doi.org/10.1684/ecn.2013.0337
Vancouver Style
Bentli R, Ciftci O, Cetin A, Unlu M, Basak N, Çay M. Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Eur Cytokine Network. 2013;24(2):91–96. https://doi.org/10.1684/ecn.2013.0337
IEEE Style
R. Bentli, O. Ciftci, A. Cetin, M. Unlu, N. Basak, and M. Çay, “Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD),” Eur. Cytokine Network, vol. 24, no. 2, pp. 91–96, 2013. https://doi.org/10.1684/ecn.2013.0337
Copyright © 2013 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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