Open Access

REVIEW

Anti-cytokine therapy and small molecule agents for the treatment of inflammatory bowel disease

Yuancong Jiang^a, Deqiang Kong^a, Xiaolong Miao, Xing Yu, Zelai Wu, Han Liu, Weihua Gong

Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou 310009, China
a These authors contributed equally to this work

* Corresponding Author: W. Gong,

European Cytokine Network 2021, 32(4), 73-82. https://doi.org/10.1684/ecn.2021.0472

Accepted 25 November 2021;

Abstract

Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, with multifactorial etiologies has led to a global health-associated burden in many countries. Substantial efforts are devoted to understand the pathogenesis, behavioral and environmental triggers, which may be specifically valuable for the treatment of IBD. The specific pathogenesis underlying IBD is as yet incompletely understood. The use of anti-cytokine therapy and small molecule agents targeting the immune system is thought to restore the body’s intestinal barrier function and relieve inflammation with manageable adverse effects. In this review, we report recent advances in anti-cytokine therapy and treatment with small molecule agents for the management of IBD.

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Keywords

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