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Effects of high molybdenum intake on 1,2-dimethylhydrazine-induced intestinal tumors in rats

M.A. MONTENEGRO*, M. SÁNCHEZ NEGRETTE*, E.J. GIMENO**, J.T. BORDA*
Faculty of Veterinary Sciences, National University of Norwest-UNNE- Argentina.
Institute of Pathology, Faculty of Veterinary Sciences, National University of La Plata, Argentina. E.J. Gimeno is a research career member from CONICET.
Corresponding Author: Marcial Sánchez Negrette, Tel/Fax: (+54- 3783) 425 753 int. 143. E-mail:

BIOCELL 2002, 26(3), 339-345. https://doi.org/10.32604/biocell.2002.26.339

Abstract

Wistar male rats, 3 months of age were given ad-libitum a nutritionally adequate diet and demineralized drinking water. The Molybdenum (Mo) and Tungsten (W) were provided in the drinking water at 200 ppm concentration. Intestinal tumors were induced by 1,2-dimethylhydrazine (DMH) given subcutaneously as 16 weekly doses at 20 mg/kg body weight. Mo in the form of (NH4)6 Mo7O24 4H2O or W in the form of (Na2 WO4) were provided in the drinking water two months before the first DMH treatment and were continued during 4 months more until the last DMH treatment. Three months after the last carcinogen injection, all animals were sacrificed and examined for intestinal tumors. The number, size and location of the tumors were recorded and the pathology was examined. The addition of Mo to the drinking water induced an increase of hepatic Mo content. At the end of the second month, the hepatic content of Mo was 5.61 ppm, compared with control and W groups (2.18 and 0.96 ppm, respectively). A significantly lower incidence of tumors was observed in the Mo group (47), compared with the control group given DMH alone (105) and W group (113). On the other hand, the Mo group showed a significant decrease in the numbers of multiple tumors per rat.

Keywords

Intestinal cancer, Molybdenum, 1,2-dimethylhydrazine, rats.

Cite This Article

MONTENEGRO, M., NEGRETTE, M. S., GIMENO, E., BORDA, J. (2002). Effects of high molybdenum intake on 1,2-dimethylhydrazine-induced intestinal tumors in rats. BIOCELL, 26(3), 339–345.



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