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Evaluation of potential embryo toxicity of albendazole sulphoxide in CF1 mice

MIRIAM TERUEL1,2, JAQUELINE D’ERCOLE1 AND RODOLFO CATALANO2
1. Area de Embriología. Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil, Argentina.
2. Area de Reproducción. Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil, Argentina.
* Address correspondence to: Miriam Teruel. Área de Embriología, Departamento de Ciencias Biológicas, Facultad de Ciencias Veterinarias, UNCPBA, Paraje Arroyo Seco s/n B7000GHG Tandil, Provincia de Buenos Aires, Argentina. Tel./Fax: (+54-2293) 439850. E-mail: mteruel@vet.unicen edu.ar

BIOCELL 2011, 35(1), 29-34. https://doi.org/10.32604/biocell.2011.35.029

Abstract

Benzimidazole compounds are used in both humans and animals for controlling helminth parasites. Albendazole has teratogenic effects attributed to its active metabolite albendazole sulphoxide. The aim of this work was to evaluate the effect of the latter compound when administered to pregnant CF1 mice during the preimplantation period. Females were superovulated by intraperitoneal injection of 10 IU of eCG and 10 IU of hCG (48h later) and were paired with males of proven fertility. Albendazole sulphoxide (200 mg/kg) was orally administered by gavages at day 1, 2 or 3 of pregnancy; the control group received only the vehicle (carboxymethylcellulose). Females were killed by cervical dislocation at day 4 of pregnancy and embryos were flushed from uteri with Ham F10 media supplemented with bovine serum albumin (0.4%). Number of collected embryos per female, percentage of morphologically normal embryos, differentiation rate and number of cells per embryos were recorded. The variables were analyzed on a per litter basis by Kruskal-Wallis test. There was no effect of albendazole sulphoxide on parameters evaluated (P>0.05). We conclude that the preimplantation mouse embryo development was not significantly affected by albendazole sulphoxide.

Keywords

benzimidazole, early pregnancy, developmental exposure.

Cite This Article

TERUEL, M., D’ERCOLE, J. (2011). Evaluation of potential embryo toxicity of albendazole sulphoxide in CF1 mice. BIOCELL, 35(1), 29–34.

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This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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