Open Access

ARTICLE

Ginkgo paste improves tinea corporis in a guinea pig model

LIHUA CAO¹, MINGSAN MIAO^1,*, YAN ZHENG², HUIYAUN HUANG², RUI ZHANG², DANDAN LIU²

1 Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, China
2 Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, 450046, China

* Address correspondence to: Mingsan Miao,

BIOCELL 2020, 44(4), 649-653. https://doi.org/10.32604/biocell.2020.05093

Received 21 December 2018; Accepted 25 February 2019; Issue published 24 December 2020

Abstract

To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model. The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains. And then, high and low doses of Ginkgo water-paste and alcohol-paste were administrated to the animals. The symptom, tinea corporis skin lesions and histopathological aspects of guinea pig were analyzed. High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste could significantly reduced the tinea corporis symptom (P < 0.01), increased negative rate of strain culture (P < 0.01), and improved pathological changes of tinea corporis (P < 0.01). The best efficacy was observed in high dose ginkgo alcohol paste group. These results suggest that Ginkgo paste exhibits the efficacy to treat tinea corporis in a guinea pig model.

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Keywords

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