Ginkgo paste improves tinea corporis in a guinea pig model
- LIHUA CAO1, MINGSAN MIAO1,*, YAN ZHENG2, HUIYAUN HUANG2, RUI ZHANG2, DANDAN LIU2
1 Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, China
2 Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, 450046, China
* Address correspondence to: Mingsan Miao,
2 Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, 450046, China
* Address correspondence to: Mingsan Miao,
Received 21 December 2018; Accepted 25 February 2019; Issue published 24 December 2020
Abstract
To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model. The guinea pig
tinea corporis model were induced by infection with Trichophyton mentagrophytes strains. And then, high and low doses of
Ginkgo water-paste and alcohol-paste were administrated to the animals. The symptom, tinea corporis skin lesions and
histopathological aspects of guinea pig were analyzed. High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste
could significantly reduced the tinea corporis symptom (P < 0.01), increased negative rate of strain culture (P < 0.01), and
improved pathological changes of tinea corporis (P < 0.01). The best efficacy was observed in high dose ginkgo alcohol
paste group. These results suggest that Ginkgo paste exhibits the efficacy to treat tinea corporis in a guinea pig model.
Keywords
Ginkgo, Alcohol paste, Tinea corporis, Guinea pig
Cite This Article
CAO, L., MIAO, M., ZHENG, Y., HUANG, H., ZHANG, R. et al. (2020). Ginkgo paste improves tinea corporis in a guinea pig model. BIOCELL, 44(4), 649–653.
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