Open Access
ARTICLE
Invasive Stratified Mucin-Producing Carcinoma (ISMC) of the uterine cervix: An analysis of 6 cases with distinctive clinicopathological features
TING LAN, SHENG QIN, XIAOJIN GONG, PING ZHENG, JIAXIN YAN, YANG LIU*
Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, UESTC, Chengdu, 610000, China
* Address correspondence to: Yang Liu,
BIOCELL 2021, 45(5), 1313-1319. https://doi.org/10.32604/biocell.2021.015923
Received 24 January 2021; Accepted 08 March 2021; Issue published 12 July 2021
Abstract
Invasive stratified mucin-producing carcinoma (ISMC) is a recently described histologic variant of high-risk
human papillomavirus (HPV)-associated endocervical adenocarcinoma, as the putative invasive counterpart of the
stratified mucin-producing intraepithelial lesion (SMILE). ISMC can display variable architectural patterns and usually
coexists with other more conventional types of HPV-associated carcinomas, which makes diagnosis and differential
diagnosis of ISMC is difficult for pathologists. Moreover, the prognosis of ISMC is still controversial. We analyzed 6
ISMCs with detailed pathological and clinical information. Intraepithelial lesion, including 1 high-grade squamous
intraepithelial lesion and 1 SMILE, was found. Various architectures were observed (including nest, glandular, solid,
trabecular, and single cell). Nuclear peripheral palisading, apoptotic bodies and mitoses, and variable cytoplasmic
mucin vacuoles were seen in all of our cases. The predominance of neutrophils infiltration was seen in only 1 tumor.
All the tumors infiltrated the cervical stroma in Silva pattern C manner. p63 and/or p40 was characteristically
expressed in the peripheral cells in only 2 cases. High-risk HPV infection was observed in 3/3 detected cases. All the
patients were alive during the follow-up time. Recognition of this infrequent tumor may help pathologists and
oncologists for an accurate diagnosis and a better understanding of the clinicopathological behavior.
Keywords
Cite This Article
APA Style
LAN, T., QIN, S., GONG, X., ZHENG, P., YAN, J. et al. (2021). Invasive stratified mucin-producing carcinoma (ISMC) of the uterine cervix: an analysis of 6 cases with distinctive clinicopathological features. BIOCELL, 45(5), 1313-1319. https://doi.org/10.32604/biocell.2021.015923
Vancouver Style
LAN T, QIN S, GONG X, ZHENG P, YAN J, LIU Y. Invasive stratified mucin-producing carcinoma (ISMC) of the uterine cervix: an analysis of 6 cases with distinctive clinicopathological features. BIOCELL . 2021;45(5):1313-1319 https://doi.org/10.32604/biocell.2021.015923
IEEE Style
T. LAN, S. QIN, X. GONG, P. ZHENG, J. YAN, and Y. LIU "Invasive Stratified Mucin-Producing Carcinoma (ISMC) of the uterine cervix: An analysis of 6 cases with distinctive clinicopathological features," BIOCELL , vol. 45, no. 5, pp. 1313-1319. 2021. https://doi.org/10.32604/biocell.2021.015923