Open Access

VIEWPOINT

New evidence for a role of Bisphenol A in cell integrity. Implications in the human population

RAFAEL MORENO-GÓMEZ-TOLEDANO^1,*, MARíA I. ARENAS², ESPERANZA VÉLEZ-VÉLEZ³, RICARDO J. BOSCH¹
1 Universidad de Alcalá, Laboratory of Renal Physiology and Experimental Nephrology, Department of Biological Systems/Physiology, 28871, Alcalá de Henares, Spain
2 Universidad de Alcalá, Cell Biology Unit, Department of Biomedicine and Biotechnology, 28871, Alcalá de Henares, Spain
3 Jiménez Díaz Foundation, Fundación Jiménez Díaz School of Nursing, Madrid, 28040, Spain
* Corresponding Author: RAFAEL MORENO-GÓMEZ-TOLEDANO. Email:

BIOCELL 2022, 46(2), 305-308. https://doi.org/10.32604/biocell.2022.017894

Received 15 June 2021; Accepted 08 July 2021; Issue published 20 October 2021

Abstract

Bisphenol A (BPA) is a xenoestrogen known for its implications for the endocrine systems and several other organs, including the kidneys. Recent renal studies have shown that BPA can induce alterations of the cytoskeleton and cell adhesion mechanisms such as a podocytopathy with proteinuria and hypertension, alterations involved in the progression of renal diseases. These data and the fact that BPA is known to be present in the urine of almost the entire population strongly suggest the critical need to reevaluate BPA exposures considered safe.

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Keywords

Bisphenol A; Podocyte; Cytoskeleton; Cell Adhesion; Chronic Renal Diseases; Dialysis

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