Open Access iconOpen Access

REVIEW

crossmark

Biochemical association between the prevalence of genetic polymorphism and myocardial infarction

MOMINA SHAHID1, KANWAL REHMAN2, MUHAMMAD SAJID HAMID AKASH1,*, SHALEEM SUHAIL1, SUMBAL RASHEED1, MUHAMMAD IMRAN3,4, MOHAMMED A. ASSIRI3,4

1 Department of Pharmaceutical Chemistry, Government College University, Faisalabad, 38000, Pakistan
2 Department of Pharmacy, The Women University, Multan, 60000, Pakistan
3 Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, 62413, Saudi Arabia
4 Department of Chemistry, Faculty of Science, King Khalid University, Abha, 62413, Saudi Arabia

* Corresponding Author: MUHAMMAD SAJID HAMID AKASH. Email: email

(This article belongs to the Special Issue: )

BIOCELL 2023, 47(3), 473-484. https://doi.org/10.32604/biocell.2023.025930

Abstract

Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction (MI). Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state. A single gene can exhibit genetic polymorphism at more than one position giving rise to different variants. Genetic polymorphism of angiotensinogen (AGT) M235T, AGT T174M, and angiotensin-1-converting enzyme (ACE) I/D, endothelial nitric oxide synthase (eNOS), and methylenetetrahydrofolate reductase (MTHFR) can be a risk factor for MI. However, it is important to study the prevalence of genetic polymorphisms of these genes among different populations. MI is influenced by genetic polymorphism of various genes, including AGT, ACE, eNOS, MTHFR, etc. However, the association of genetic polymorphism of these genes varies among different populations, but different ethnic groups could show contradictory results. These genes have shown a positive association with risks of MI in some populations, whereas the results have not been consistent with every ethnic group. In this article, we have summarized the genetic variations in the aforementioned genes and their association with MI.

Keywords


Cite This Article

APA Style
SHAHID, M., REHMAN, K., AKASH, M.S.H., SUHAIL, S., RASHEED, S. et al. (2023). Biochemical association between the prevalence of genetic polymorphism and myocardial infarction. BIOCELL, 47(3), 473-484. https://doi.org/10.32604/biocell.2023.025930
Vancouver Style
SHAHID M, REHMAN K, AKASH MSH, SUHAIL S, RASHEED S, IMRAN M, et al. Biochemical association between the prevalence of genetic polymorphism and myocardial infarction. BIOCELL . 2023;47(3):473-484 https://doi.org/10.32604/biocell.2023.025930
IEEE Style
M. SHAHID et al., "Biochemical association between the prevalence of genetic polymorphism and myocardial infarction," BIOCELL , vol. 47, no. 3, pp. 473-484. 2023. https://doi.org/10.32604/biocell.2023.025930



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 1125

    View

  • 408

    Download

  • 0

    Like

Share Link