Open Access
ARTICLE
Evaluation of Biventricular Volume and Systolic Function in Children with Ventricular Septal Defect and Moderate to Severe Pulmonary Hypertension Using Real-Time Three-Dimensional Echocardiography
Huan Zhou1,#, Jin Kang2,#, Jun Gao2,*, Xiaoyuan Feng1, Li Zhou2, Xia Xiao2, Zhengliang Meng2, Chengwen Guo2
1
Children’s Heart Center, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College,
Huazhong University of Science & Technology, Wuhan, China
2
Department of Ultrasound, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College,
Huazhong University of Science & Technology, Wuhan, China
* Corresponding Author: Jun Gao. Email:
# These authors contributed equally
Congenital Heart Disease 2022, 17(6), 697-707. https://doi.org/10.32604/chd.2022.022648
Received 18 March 2022; Accepted 06 June 2022; Issue published 11 October 2022
Abstract
Background: Real-time three-dimensional echocardiography (RT-3DE) could obtain ventricular volume and
ejection fraction rapidly and non-invasively without relying on ventricular morphology. This study aims to use
RT-3DE to evaluate the changes in biventricular volume and systolic function in children with ventricular septal
defect (VSD) and moderate to severe pulmonary hypertension (PH) before surgery.
Methods: In this study
18 children with VSD and moderate to severe PH (VSD + PH Group) and 18 healthy children of the same
age (Control Group) were recruited. Biventricular volume and systolic function were evaluated by RT-3DE.
The measurements included: left and right ventricular volume indexed to body surface area (BSA), stroke volume
(SV) indexed to BSA, and ejection fraction (EF).
Results: The results showed left and right ventricular volume
indexed to BSA and SV indexed to BSA were significantly increased in VSD + PH Group (VSD + PH Group
vs. Control Group), LVEDV/BSA (ml/m
2
): 48.67 ± 21.46
vs. 25.59 ± 6.96, RVEDV/BSA (ml/m
2
): 55.98 ±
15.35
vs. 27.69 ± 4.37, LVSV/BSA (ml/m
2
): 24.08 ± 9.30
vs. 15.14 ± 4.29, RVSV/BSA (ml/m
2
): 26.02 ± 8.87
vs.
14.11 ± 2.89, (
P < 0.05). While for EF in VSD + PH Group decreased (VSD + PH Group
vs. Control Group),
LVEF: 50.93 ± 7.50%
vs. 59.38 ± 7.24%, RVEF: 45.84 ± 7.71%
vs. 51.05 ± 6.90% (
P < 0.05).
Conclusion: In children with VSD and moderate to severe PH, increased biventricular volume and decreased systolic function were
observed with RT-3DE, but biventricular systolic function remained within acceptable limits. The children in this
study recovered well after surgery without serious perioperative complications, suggesting that biventricular systolic function may help facilitate the surgical decision-making process in children with VSD and moderate-tosevere PH.
Graphical Abstract
Keywords
Cite This Article
Zhou, H., Kang, J., Gao, J., Feng, X., Zhou, L. et al. (2022). Evaluation of Biventricular Volume and Systolic Function in Children with Ventricular Septal Defect and Moderate to Severe Pulmonary Hypertension Using Real-Time Three-Dimensional Echocardiography.
Congenital Heart Disease, 17(6), 697–707.