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Forced vital capacity predicts morbidity and mortality in adults with repaired tetralogy of Fallot

Katie E. Cohen1, Matthew W. Buelow1, Jennifer Dixon1, Ruta Brazauskas2, Scott B. Cohen3, Michael G. Earing1,3, Salil Ginde1

1 Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin
2 Department of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin
3 Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin

* Corresponding Author: Salil Ginde, Children’s Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226. Email: email

Congenital Heart Disease 2017, 12(4), 435-440. https://doi.org/10.1111/chd.12470

Abstract

Objective: Abnormal lung function characterized by a reduced forced vital capacity (FVC) is common in adults with repaired tetralogy of Fallot (TOF) and is associated with previous thoracotomies and sternotomies. The impact of abnormal lung function on clinical outcomes in adult patients with repaired TOF is unclear. The aim of this study was to determine the impact of abnormal lung function on the outcome of hospitalization and death in adults with repaired TOF when analyzed with other traditional cardiac risk factors.
Design: Retrospective study of adults with repaired TOF, who underwent spirometry between 2000 and 2014. FVC < 60% of predicted was categorized as moderate-to-severely reduced lung function. Primary outcome measure was the combined clinical endpoint of death, cardiac transplantation, or nonelective hospitalization for primary cardiac or respiratory indication.
Results: A total of 122 patients were included. Average age at spirometry testing was 31 ± 10.1 years. FVC was < 60% predicted in 23 (19%) patients. During a mean follow-up period of 3.97 ± 2.65 years, 23 (19%) patients reached the combined clinical outcome of nonelective hospitalization and/or death. FVC < 60% predicted was independently associated with the risk for the combined clinical outcome (RR 6.68 (95% CI 2.49–17.94), P < .001).
Conclusions: Abnormal pulmonary function characterized by reduced FVC is common in adults with repaired TOF. Patients with FVC < 60% predicted had a 6 times higher rate of hospitalization and/or death compared to those with FVC ≥60%.

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APA Style
Cohen, K.E., Buelow, M.W., Dixon, J., Brazauskas, R., Cohen, S.B. et al. (2017). Forced vital capacity predicts morbidity and mortality in adults with repaired tetralogy of fallot. Congenital Heart Disease, 12(4), 435-440. https://doi.org/10.1111/chd.12470
Vancouver Style
Cohen KE, Buelow MW, Dixon J, Brazauskas R, Cohen SB, Earing MG, et al. Forced vital capacity predicts morbidity and mortality in adults with repaired tetralogy of fallot. Congeni Heart Dis. 2017;12(4):435-440 https://doi.org/10.1111/chd.12470
IEEE Style
K.E. Cohen et al., "Forced vital capacity predicts morbidity and mortality in adults with repaired tetralogy of Fallot," Congeni. Heart Dis., vol. 12, no. 4, pp. 435-440. 2017. https://doi.org/10.1111/chd.12470



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