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Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Yumi Shiina1, Tomoaki Murakami2, Noriko Matsumoto3, Daisuke Okamura4, Yuta Takahashi4, Yosuke Nishihata1, Nobuyuki Komiyama1, Koichiro Niwa1

1 Department of Cardiology, Cardiovascular Center, St. Luke’s International Hospital, Tokyo, Japan
2 Department of Cardiology, Chiba Children’s Hospital, Chiba, Japan
3 Department of Nutrition, St. Luke’s International Hospital, Tokyo, Japan
4 Department of rehabilitation, St. Luke’s International Hospital, Tokyo, Japan

* Corresponding Author: Tomoaki Murakami, MD, PhD, Department of Cardiology, Chiba Children’s Hospital, 579-1 Heta-cho, Midori-ku, Chiba 266- 0007 Japan. Email: email

Congenital Heart Disease 2018, 13(1), 79-84. https://doi.org/10.1111/chd.12555

Abstract

Objectives: To assess body composition and relationships among body composition, appetiterelated hormones, adipocytokines, and heart failure (HF) in adult patients with congenital heart disease (CHD).
Patients: This prospective study enrolled 46 consecutive adult patients with CHD and 12 agematched healthy controls. The patients and control subjects were divided into four groups: 13 patients with Fontan circulation (group A), 16 patients with cyanosis (group B), 17 patients who previously underwent biventricular repair (group C), and 12 age-matched healthy controls.
Design: Body composition was measured using InBody730, and levels of appetite-related hormones (ghrelin and leptin) and adipocytokines (leptin, interleukin-6, and tumor necrosis factor-a) were determined. Relationships of these measurements between severe HF, defined as New York Heart Association functional class III–IV and/or recent repeated unscheduled hospitalizations due to HF, were examined using univariate logistic analysis.
Results: Mean patient age was 32.1 ± 7.4 years. The skeletal muscle mass was significantly decreased in groups A and B compared with that in controls. Interestingly, ghrelin levels in groups A and B were also significantly lower than those in controls. Univariate logistic analysis revealed that ghrelin level, percent body fat, and pulse oximetric oxygen saturation were significantly associated with severe HF.
Conclusions: Patients with Fontan circulation and those with cyanosis might be at a risk of sarcopenia. Despite the decreased skeletal muscle mass and increased body fat, ghrelin levels in these patients were decreased. These changes might have a negative impact on HF in these patients.

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APA Style
Shiina, Y., Murakami, T., Matsumoto, N., Okamura, D., Takahashi, Y. et al. (2018). Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study. Congenital Heart Disease, 13(1), 79-84. https://doi.org/10.1111/chd.12555
Vancouver Style
Shiina Y, Murakami T, Matsumoto N, Okamura D, Takahashi Y, Nishihata Y, et al. Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study. Congeni Heart Dis. 2018;13(1):79-84 https://doi.org/10.1111/chd.12555
IEEE Style
Y. Shiina et al., "Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study," Congeni. Heart Dis., vol. 13, no. 1, pp. 79-84. 2018. https://doi.org/10.1111/chd.12555



cc Copyright © 2018 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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