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Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Yumi Shiina1, Tomoaki Murakami2, Noriko Matsumoto3, Daisuke Okamura4, Yuta Takahashi4, Yosuke Nishihata1, Nobuyuki Komiyama1, Koichiro Niwa1
1 Department of Cardiology, Cardiovascular Center, St. Luke’s International Hospital, Tokyo, Japan
2 Department of Cardiology, Chiba Children’s Hospital, Chiba, Japan
3 Department of Nutrition, St. Luke’s International Hospital, Tokyo, Japan
4 Department of rehabilitation, St. Luke’s International Hospital, Tokyo, Japan
* Corresponding Author: Tomoaki Murakami, MD, PhD, Department of Cardiology, Chiba Children’s Hospital, 579-1 Heta-cho, Midori-ku, Chiba 266- 0007 Japan. Email:

Congenital Heart Disease 2018, 13(1), 79-84. https://doi.org/10.1111/chd.12555

Abstract

Objectives: To assess body composition and relationships among body composition, appetiterelated hormones, adipocytokines, and heart failure (HF) in adult patients with congenital heart disease (CHD).
Patients: This prospective study enrolled 46 consecutive adult patients with CHD and 12 agematched healthy controls. The patients and control subjects were divided into four groups: 13 patients with Fontan circulation (group A), 16 patients with cyanosis (group B), 17 patients who previously underwent biventricular repair (group C), and 12 age-matched healthy controls.
Design: Body composition was measured using InBody730, and levels of appetite-related hormones (ghrelin and leptin) and adipocytokines (leptin, interleukin-6, and tumor necrosis factor-a) were determined. Relationships of these measurements between severe HF, defined as New York Heart Association functional class III–IV and/or recent repeated unscheduled hospitalizations due to HF, were examined using univariate logistic analysis.
Results: Mean patient age was 32.1 ± 7.4 years. The skeletal muscle mass was significantly decreased in groups A and B compared with that in controls. Interestingly, ghrelin levels in groups A and B were also significantly lower than those in controls. Univariate logistic analysis revealed that ghrelin level, percent body fat, and pulse oximetric oxygen saturation were significantly associated with severe HF.
Conclusions: Patients with Fontan circulation and those with cyanosis might be at a risk of sarcopenia. Despite the decreased skeletal muscle mass and increased body fat, ghrelin levels in these patients were decreased. These changes might have a negative impact on HF in these patients.

Keywords

body fat, congenital heart disease, ghrelin, heart failure, muscle mass

Cite This Article

Shiina, Y., Murakami, T., Matsumoto, N., Okamura, D., Takahashi, Y. et al. (2018). Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study. Congenital Heart Disease, 13(1), 79–84.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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