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The effect of right ventricular function on survival and morbidity following stage 2 palliation: An analysis of the single ventricle reconstruction trial public data set

Vanessa Marie Hormaza1, Mark Conaway2, Daniel Scott Schneider1, Jeffrey Eric Vergales1

1 Division of Cardiology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia
2 Division of Translational Research and Statistics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia

* Corresponding Author: Vanessa Marie Hormaza, MD, Children’s Hospital Heart Center, University of Virginia Health System, P.O. Box 800386, Charlottesville, VA 22908. Email: email

Congenital Heart Disease 2019, 14(2), 274-279. https://doi.org/10.1111/chd.12722

Abstract

Objective: Limited information is known on how right ventricular function affects outcomes after stage 2 palliation. We evaluated the impact of different right ventricular indices prior to stage 2 palliation on morbidity and mortality.
Design: Retrospective study design.
Setting: Pediatric Heart Network Single Ventricle Reconstruction Trial Public Data Set.
Patient: Any variant of stage 1 palliation and all anatomic hypoplastic left heart syndrome variants in the trial were evaluated. Echocardiograms prior to stage 2 palliation were analyzed and compared between those who failed and those who survived.
Intervention: None.
Outcome measures: Mortality was defined as death, listed for transplant, or transplanted after stage 2 palliation. Morbidity was evaluated as hospital length of stay and duration of intubation.
Results: A total of 283 patients met criteria for analysis. Of those, only 18 patients failed stage 2. Right ventricular fractional area change was less in those who failed (30% vs 34%, P = .039) and right ventricular indexed end‐diastolic volume and end‐ systolic volume were larger in those who failed (142.74 mL/ BSA1.3 vs 111.29 mL/ BSA1.3, P = .023, 88.45 mL/ BSA1.3 vs 62.75 mL/ BSA1.3, P = .025, respectively). Larger right ventricular indexed end‐diastolic and systolic volumes were associated with failure (OR 1.17 [1.01‐1.35] P = .021, OR 1.25 [1.03‐1.52] P = .021, respectively). Every 10% increase in RV ejection fraction had a 63% decrease in length of stay and a 68% decrease in duration of intubation (P = .014, and P = .039, respectively).
Conclusion: Patients with decreased right ventricular fractional area change and larger right ventricular indexed end‐diastolic and systolic volumes were more likely to fail stage 2 palliation. Those with preserved right ventricular function had a shorter hospital length of stay and duration of intubation. Echocardiographic measurements of right ventricular indices during the interstage period can be utilized to determine the prognosis following stage 2 palliation.

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Cite This Article

Hormaza, V. M., Conaway, M., Schneider, D. S., Vergales, J. E. (2019). The effect of right ventricular function on survival and morbidity following stage 2 palliation: An analysis of the single ventricle reconstruction trial public data set. Congenital Heart Disease, 14(2), 274–279.



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